PRDX4

Protein identityUniProt · HPA

UniProt accession

Q13162

Gene

PRDX4

Ensembl

ENSG00000123131

Chromosome

X

Canonical length

271 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Subcellular location

Endoplasmic reticulum,Cytosol

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q13162|PRDX4
     1  MEALPLLAAT TPDHGRHRRL LLLPLLLFLL PAGAVQGWET EERPRTREEE CHFYAGGQVY
    61  PGEASRVSVA DHSLHLSKAK ISKPAPYWEG TAVIDGEFKE LKLTDYRGKY LVFFFYPLDF
   121  TFVCPTEIIA FGDRLEEFRS INTEVVACSV DSQFTHLAWI NTPRRQGGLG PIRIPLLSDL
   181  THQISKDYGV YLEDSGHTLR GLFIIDDKGI LRQITLNDLP VGRSVDETLR LVQAFQYTDK
   241  HGEVCPAGWK PGSETIIPDP AGKLKYFDKL N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

1,143 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDX4.

Disease | ImmuneIEDB

Conditions an epitope on PRDX4 was assayed in.

• onchocerciasis B cell
• brain glioma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0.03

gnomAD missense Z

1.04

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• extracellular matrix organization
• hydrogen peroxide catabolic process
• I-kappaB phosphorylation
• male gonad development
• negative regulation of male germ cell proliferation
• protein maturation
• response to oxidative stress
• spermatogenesis

Molecular functions

• identical protein binding
• molecular adaptor activity
• molecular sequestering activity
• thioredoxin peroxidase activity

Cellular components

• cytosol
• endoplasmic reticulum
• extracellular exosome
• extracellular region
• ficolin-1-rich granule lumen
• nucleus
• secretory granule lumen

Protein domainsUniProt · Pfam · InterPro

• Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
• Thioredoxin domain
• Peroxiredoxin, C-terminal
• Thioredoxin-like superfamily
• Thiol-specific antioxidant peroxiredoxin
• AhpC/TSA family
• C-terminal domain of 1-Cys peroxiredoxin

KeywordsUniProt

• Antioxidant
• Cytoplasm
• Disulfide bond
• Endoplasmic reticulum
• Oxidoreductase
• Peroxidase
• Redox-active center
• Signal

InteractionsUniProt · HPA

Protein binding partners of PRDX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NR4A1
• PRDX1
• TBXA2R