Seroatlas · Human Serome Atlas

IER5

Immediate early response gene 5 protein

Also known as: IER5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VY09
Gene
IER5
Ensembl
ENSG00000162783
Chromosome
1
Canonical length
327 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q5VY09|IER5
     1  MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD PCPGLYLAGP
    61  AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP QPERSSVSDA PRVGDEVPVA
   121  TVTGVGDVFQ GGEADATEAA WSRVEGPRQA AAREAEGTAG GWGVFPEVSR AARRPCGCPL
   181  GGEDPPGTPA ATPRAACCCA PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK
   241  KPRRNLEQPP SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE
   301  AAEPGQICCD KPVLRDMNPW STAIVAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IER5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 47 nTPM
  • skeletal muscle: 32 nTPM
  • spleen: 32 nTPM
  • heart muscle: 27 nTPM
  • esophagus: 26 nTPM
  • lung: 22 nTPM

Single-cell type

  • breast hormone-responsive cells: 285 nCPM
  • cdc: 283 nCPM
  • kupffer cells: 264 nCPM
  • monocytes: 254 nCPM
  • macrophages: 237 nCPM
  • epididymal basal cells: 214 nCPM

Immune cell

  • intermediate monocyte: 5.5 nTPM
  • non-classical monocyte: 5.3 nTPM
  • memory B-cell: 4.1 nTPM
  • basophil: 3.6 nTPM
  • naive B-cell: 3 nTPM
  • eosinophil: 2.7 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • white matter: 16 nTPM
  • choroid plexus: 13 nTPM
  • hypothalamus: 12 nTPM
  • hippocampal formation: 11 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.87
gnomAD missense Z
0
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IER5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IER5 as an antibody target. Whether an autoantibody or antibody against IER5 could matter depends on whether native IER5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IER5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IER5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IER5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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