Seroatlas · Human Serome Atlas

ARPP19

cAMP-regulated phosphoprotein 19

Also known as: ARP19_HUMAN, ARPP-16, ARPP-19, ARPP16, ENSAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56211
Gene: ARPP19
Ensembl: ENSG00000128989
Chromosome: 15
Canonical length: 112 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Vesicles,Basal body,Cytosol

OverviewNCBI Gene

The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>P56211|ARPP19
     1  MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR KRLQKGQKYF
    61  DSGDYNMAKA KMKNKQLPTA APDKTEVTGD HIPTPQDLPQ RKPSLVASKL AG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPP19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 481 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 481 nTPM
cerebral cortex: 292 nTPM
skeletal muscle: 225 nTPM
amygdala: 179 nTPM
spinal cord: 171 nTPM
tongue: 159 nTPM

Single-cell type

late spermatids: 5,539 nCPM
early spermatids: 862 nCPM
parietal cells: 221 nCPM
differentiating spermatogonia: 220 nCPM
alveolar cells type 1: 208 nCPM
basal keratinocytes: 192 nCPM

Immune cell

eosinophil: 89 nTPM
T-reg: 80 nTPM
memory B-cell: 70 nTPM
NK-cell: 66 nTPM
neutrophil: 64 nTPM
memory CD8 T-cell: 57 nTPM

Brain region

basal ganglia: 511 nTPM
cerebral cortex: 288 nTPM
white matter: 242 nTPM
spinal cord: 203 nTPM
medulla oblongata: 198 nTPM
hypothalamus: 194 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.77
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPP19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPP19 as an antibody target. Whether an autoantibody or antibody against ARPP19 could matter depends on whether native ARPP19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPP19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPP19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...