Seroatlas · Human Serome Atlas

SERTAD4

SERTA domain-containing protein 4

Also known as: DJ667H12.2, SRTD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUC0
Gene: SERTAD4
Ensembl: ENSG00000082497
Chromosome: 1
Canonical length: 356 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9NUC0|SERTAD4
     1  MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD RGAGPPLAGS
    61  HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS IFEERAHILY MSLEKLKFID
   121  DPEVYLRRSV LINNLMKRIH GEIIMQNNWC FPACSFNGTS AQEWFMAQDC PYRKRPRMAK
   181  EECEKFHACC FYQECGGHYL NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC
   241  SRQVDFDVGS ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE
   301  PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC SKGSKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERTAD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 5.6 nTPM
colon: 4.5 nTPM
basal ganglia: 4.3 nTPM
esophagus: 4 nTPM
blood vessel: 3.7 nTPM
endometrium: 3.6 nTPM

Single-cell type

brain inhibitory neurons: 8.5 nCPM
extravillous trophoblasts: 8.1 nCPM
oligodendrocytes: 6.7 nCPM
renal collecting duct principal cells: 6 nCPM
other brain neurons: 5.9 nCPM
brain excitatory neurons: 5.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 3.4 nTPM
midbrain: 2.9 nTPM
spinal cord: 2.5 nTPM
cerebral cortex: 2.2 nTPM
white matter: 2.2 nTPM
hypothalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.03
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

SERTA domain
SERTA motif
SERTA domain-containing protein 4

InteractionsUniProt · HPA

Protein binding partners of SERTAD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERTAD4 as an antibody target. Whether an autoantibody or antibody against SERTAD4 could matter depends on whether native SERTAD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERTAD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERTAD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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