Seroatlas · Human Serome Atlas

CRIPT

Cysteine-rich PDZ-binding protein

Also known as: CRIPT_HUMAN, HSPC139

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P021
Gene
CRIPT
Ensembl
ENSG00000119878
Chromosome
2
Canonical length
101 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>Q9P021|CRIPT
     1  MVCEKCEKKL GTVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY GKNKFSTCRI
    61  CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
9.9 nTPM

Expression across tissuesHPA

Tissue

  • retina: 9.9 nTPM
  • bone marrow: 5.6 nTPM
  • epididymis: 5.2 nTPM
  • spinal cord: 4.8 nTPM
  • cerebellum: 4.7 nTPM
  • amygdala: 4.2 nTPM

Single-cell type

  • esophageal apical cells: 218 nCPM
  • syncytiotrophoblasts: 117 nCPM
  • extravillous trophoblasts: 112 nCPM
  • esophageal suprabasal cells: 110 nCPM
  • parietal cells: 104 nCPM
  • breast lactating cells: 97 nCPM

Immune cell

  • basophil: 6.2 nTPM
  • neutrophil: 5.2 nTPM
  • eosinophil: 3.8 nTPM
  • memory B-cell: 3.6 nTPM
  • T-reg: 3.6 nTPM
  • naive B-cell: 3.5 nTPM

Brain region

  • cerebellum: 31 nTPM
  • white matter: 30 nTPM
  • cerebral cortex: 27 nTPM
  • medulla oblongata: 27 nTPM
  • choroid plexus: 27 nTPM
  • hippocampal formation: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRIPT.

Disease | AllUniProt

Conditions CRIPT is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 92 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
-0.39
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PDZ-binding protein, CRIPT
  • Microtubule-associated protein CRIPT

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRIPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIPT as an antibody target. Whether an autoantibody or antibody against CRIPT could matter depends on whether native CRIPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIPT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRIPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRIPT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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