Seroatlas · Human Serome Atlas

CEP126

Centrosomal protein of 126 kDa

Also known as: CE126_HUMAN, KIAA1377

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2H0
Gene
CEP126
Ensembl
ENSG00000110318
Chromosome
11
Canonical length
1117 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in cilium assembly; cytoplasmic microtubule organization; and mitotic spindle organization. Located in centrosome; ciliary base; and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1117 residues, UniProt reviewed canonical sequence.

>Q9P2H0|CEP126
     1  MLAGRPGTRS AVGELGTESS DNLDRAPLGP RESGGHHRPG SYLDMKIHLE KNLEEERQIL
    61  LQQQKICRNR ARKYFVESNR RKKAFEEKRK EQEEKEHQIR EQILQQRKQK FEEVTEKFQR
   121  AHVPLSQRRK AVSRKPVPPL EEALKQIQES NLKSEVNLPF SRRPTINWRA IDSALPSALS
   181  KNDHKHQKQL LSKINCEKEM NENMRATLAT SKNVFQLKLE ETQKLLEDQH LSNLQKFCDE
   241  VNQITNSETL SSIDSLEATE HEEIYLTLNK EHSTSIQRNT ISLKPANMQS TNLSCFDEDK
   301  LAFSKTQHIN NWLTNLDASN TQNVTAFSDI LSKSNVLPSW EYFNSKEQNP SPLNGTVERA
   361  TNTANNSVPF VSSPPMFVLD KKCEKTSETS TMRTTDSTSG AFKRERPLVT ESPTFKFSKS
   421  QSTSDSLTQE VATFPDQEKY SELNQENGTT SIPTSCVPVA TPLVLPSNIQ SARPSAKNSI
   481  HIKEIDAVQC SDKLDELKDG KEEEIKYFNC NKEELPLFSD SFQDAYIPHN PDSKDEKQKL
   541  AETSSLSNVT SNYDFVGQHK KMKYNIHERN GVRFLKSILK KESKYEHGYL KALIINQSFK
   601  FGNQKAAAIR DSIELTKEKG AEIPKTIKKL RWFDETSNIE NNAENSHSLK NKTGTTQQHS
   661  QQFHIQSGAG SNIISVSTCA VNSADTKKSR EDSISENVTT LGGSGADHMP LNCFIPSGYN
   721  FAKHAWPASK KEESKIPVHD DSKTKQGKPQ RGRAKIIRKP GSAKVQSGFI CTNRKGAVIQ
   781  PQSASKVNIF TQAQGKLIIP CPPPQSTSNI RSGKNIQVSQ CQPVTPENPQ NIITHNSFNS
   841  KHVLPTEHSL NQWNQESSSP LSNACSDLVT VIPSLPSYCS SECQTFAKIN HSNGTQAVAR
   901  QDATLYCTQR SPVCEESYPS VTLRTAEEES VPLWKRGPNV LHQNKRATGS TVMRRKRIAE
   961  TKRRNILEQK RQNPGSVGQK YSEQINNFGQ SVLLSSSEPK QTTRGTSYIE EVSDSTSEFL
  1021  MAENLVKASV PEDEILTVLN SKQIQKSNLP LNKTQQFNIC TLSAEEQKIL ESLNDLSERL
  1081  HYIQESICKN PSIKNTLQII PLLEKREDRT SSCRDKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP126 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 39 nTPM
  • pituitary gland: 17 nTPM
  • testis: 16 nTPM
  • retina: 10 nTPM
  • basal ganglia: 8.6 nTPM
  • ovary: 7.8 nTPM

Single-cell type

  • ependymal cells: 837 nCPM
  • respiratory ciliated cells: 803 nCPM
  • somatotrophs: 691 nCPM
  • thyrotrophs: 685 nCPM
  • fallopian tube ciliated cells: 603 nCPM
  • choroid plexus epithelial cells: 397 nCPM

Immune cell

  • plasmacytoid DC: 1.1 nTPM
  • NK-cell: 0.9 nTPM
  • naive B-cell: 0.6 nTPM
  • gdT-cell: 0.4 nTPM
  • memory B-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • basal ganglia: 17 nTPM
  • medulla oblongata: 16 nTPM
  • cerebellum: 16 nTPM
  • spinal cord: 16 nTPM
  • midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centrosomal protein of 126kDa
  • Susceptibility to monomelic amyotrophy

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP126 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP126 as an antibody target. Whether an autoantibody or antibody against CEP126 could matter depends on whether native CEP126 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP126 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP126 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP126. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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