Seroatlas · Human Serome Atlas

DCDC1

Doublecortin domain-containing protein 1

Also known as: DCDC1_HUMAN, DCDC5, FLJ46154

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: M0R2J8
Gene: DCDC1
Ensembl: ENSG00000170959
Chromosome: 11
Canonical length: 1783 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

1783 residues, UniProt reviewed canonical sequence.

>M0R2J8|DCDC1
     1  MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL NDLPREFMSS
    61  QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH QTASDHSHDE ISDLDSYKSN
   121  SKNNSCSISA SKRNRPVSAP VGQLRVAEFS SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK
   181  NGSRTVFARV TVPTITLLLE ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG
   241  EPFLNPFKKI KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF
   301  KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS KVPLLEKCLQ
   361  NSITPLRGLL WVSKGEGFSP SGAKMYIQGV LLALYQRLKS AKKYYKQLNL VMNEQKEKIT
   421  EKVILSMTAK EHHKEQEEVS RLIDELQTAI KSNIGHLCKL GPQLQAEQEQ FSSYVYQHIK
   481  SLPANTLVPG GLQLKVFENG KNTGEISVGI SKKDLGSDSP IQTDHMMERL LLKIHQRLQG
   541  SSINPPGLNY SSMRLFDENG QEIKNPLSLK NEQKIWVSYG RAYRSPLNLA LGLTFDRVSA
   601  FARGDIMVAY KTFLDPNAVL LPGCGNWEVC EGFPINFNCT SQQIPDQFEK VDLENHFLQN
   661  KVDPNIVLHA SVSIGKWSFS GSEASSRSQI APSILWPVAS VWLITKTGMI LSRAITQGCL
   721  AIGHPIRVKA AEGTSLEGYK LILQKRHSGD DSQKWVFGTD GCIYSKAYPQ FVLTYLEELN
   781  AQVDVTQTEY HIHHGAWTTA HQEHGRNLAE EVLQESASNL GLKQLPEPSD THLMPEGSLE
   841  ETGELTVALV RKLEEKHPKA SAQRWAIKHE GTSKPGQWKH SRVENPLWNK LTYMWPVLPS
   901  GQLNEEFDWP IQGLLVPSSP PMKKPICKTT EPYAPVRLRV LQNGEKNKNR SVTILGPDIS
   961  PGRKTQCTEI LNLPSAARRL YNEKGKEIFA LKDLQRDELV YVSCGELWIN PDLSIAQQKK
  1021  QIFLRNLESD IAKIQIFCST HKIEALVLEV QSDIVSGSKL AVHKPVAIFG EEKQVTEPEE
  1081  KQMQEDPLTT ENASSEILDS HVRAHLRMKA CHTLPRYAWQ ETSHDFDEDD SLPKKTEKGL
  1141  FENVEPQKKH SCSPKHSKLH KHCHQQFEYR DGQIISHAAP QLVLGVQGPN LRSGMEVVLV
  1201  EKKSDGSHQR WIHQEDSRTF HLVSNPDLVL AVSMTKTRNE VCGYPVIVQK YKPYNNGAAN
  1261  QKWHYMKNIK ALVAFHSTAL DKEITSANYA GVCTSSVIKE ENIDQPGYCY LSPDGKRKTM
  1321  LCLACGQSMR TEKGLKQLLP GVPFLCISGT KTQKPFLQGP FKVISVAEVD LSCDKAEKTL
  1381  SYYQARLLSL RMKTCTQAAS HSGMAATHQK AVKIIAYKNG DGYRNGKLIV AGTFPMLLTE
  1441  CTEQLGLARA ASKVYTKDGT PIFTLRDLVL WALDESFLQR DSEKQKQDAA PVGKEQIIVE
  1501  KNPRMKVKNR LFAKSVTSDS LDGIDKSLLT LILRNPIAIW VSCGEPFLPP NALQKAEKLE
  1561  KQNWLKKDRI LADLDTMRHK MRQLKGRRVA ACQPATMVPT KSPVQPVVVE GGWTEQTQQE
  1621  IKLMELIRHT EAHLSEIQEM ESKINFPIAT KRIAVKPSNL YKQPNTKRVW IYLNGGRPED
  1681  GTYAWGKTIS ELLQDCSSRL KMTHPARALY TPSGEPIQSW DDIERDMVIC VSMGHGFKTP
  1741  KELKQLMEIR ANYARIRRQQ GPQATDIVVS PSTKLLSLAH LHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 2.7 nTPM
retina: 2.7 nTPM
choroid plexus: 2.6 nTPM
liver: 2.6 nTPM
testis: 1.9 nTPM
gallbladder: 1.6 nTPM

Single-cell type

ependymal cells: 1,942 nCPM
respiratory ciliated cells: 1,301 nCPM
retinal ganglion cells: 861 nCPM
choroid plexus epithelial cells: 752 nCPM
endometrial ciliated cells: 582 nCPM
fallopian tube ciliated cells: 549 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 21 nTPM
medulla oblongata: 10 nTPM
midbrain: 9.7 nTPM
spinal cord: 7.2 nTPM
hippocampal formation: 5.1 nTPM
pons: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCDC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Susceptibility to severe COVID-19

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Doublecortin domain
Ricin B-like lectins
Doublecortin domain superfamily
Doublecortin domain-containing protein 1
DCDC1, second doublecortin-like domain
Doublecortin domain-containing protein 1-like, ubiquitin domain
DCDC1, second doublecortin-like domain
Doublecortin domain-containing protein 1-like, ubiquitin domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCDC1 as an antibody target. Whether an autoantibody or antibody against DCDC1 could matter depends on whether native DCDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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