Seroatlas · Human Serome Atlas

TSPAN1

Tetraspanin-1

Also known as: NET-1, TSN1_HUMAN, TSPAN-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60635
Gene: TSPAN1
Ensembl: ENSG00000117472
Chromosome: 1
Canonical length: 241 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>O60635|TSPAN1
     1  MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA MQFVNVGYFL
    61  IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE VAAAVVALVY TTMAEHFLTL
   121  LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC GFTNYTDFED SPYFKENSAF PPFCCNDNVT
   181  NTANETCTKQ KAHDQKVEGC FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL
   241  Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 556 nTPM

Expression across tissuesHPA

Tissue

rectum: 556 nTPM
colon: 490 nTPM
kidney: 233 nTPM
stomach: 201 nTPM
prostate: 183 nTPM
thyroid gland: 114 nTPM

Single-cell type

colonocytes: 1,954 nCPM
conjunctival goblet cells: 1,778 nCPM
respiratory ciliated cells: 1,602 nCPM
late spermatids: 1,580 nCPM
salivary duct cells: 1,518 nCPM
respiratory secretory cells: 1,005 nCPM

Immune cell

plasmacytoid DC: 5.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 3.3 nTPM
cerebellum: 3.2 nTPM
choroid plexus: 2.6 nTPM
medulla oblongata: 2.2 nTPM
spinal cord: 1.8 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein stabilization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN1 as an antibody target. Whether an autoantibody or antibody against TSPAN1 could matter depends on whether native TSPAN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN1 is annotated at the cell surface, where native TSPAN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...