Seroatlas · Human Serome Atlas

TRPV1

Transient receptor potential cation channel subfamily V member 1

Also known as: TRPV1_HUMAN, VR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NER1
Gene: TRPV1
Ensembl: ENSG00000196689
Chromosome: 17
Canonical length: 839 aa
Protein class: FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure: Homotetramer

OverviewNCBI Gene

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

839 residues, UniProt reviewed canonical sequence.

>Q8NER1|TRPV1
     1  MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF GKGDSEEAFP
    61  VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD SVAASTEKTL RLYDRRSIFE
   121  AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI
   181  ARQTDSLKEL VNASYTDSYY KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT
   241  KGRPGFYFGE LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA
   301  DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL AYILQREIQE
   361  PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI AYSSSETPNR HDMLLVEPLN
   421  RLLQDKWDRF VKRIFYFNFL VYCLYMIIFT MAAYYRPVDG LPPFKMEKTG DYFRVTGEIL
   481  SVLGGVYFFF RGIQYFLQRR PSMKTLFVDS YSEMLFFLQS LFMLATVVLY FSHLKEYVAS
   541  MVFSLALGWT NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE
   601  DGKNDSLPSE STSHRWRGPA CRPPDSSYNS LYSTCLELFK FTIGMGDLEF TENYDFKAVF
   661  IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL QRAITILDTE KSFLKCMRKA
   721  FRSGKLLQVG YTPDGKDDYR WCFRVDEVNW TTWNTNVGII NEDPGNCEGV KRTLSFSLRS
   781  SRVSGRHWKN FALVPLLREA SARDRQSAQP EEVYLRQFSG SLKPEDAEVF KSPAASGEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

liver: 22 nTPM
cerebellum: 12 nTPM
retina: 12 nTPM
ovary: 9.4 nTPM
small intestine: 7.7 nTPM
cervix: 7.6 nTPM

Single-cell type

rod photoreceptor cells: 26 nCPM
myonuclei: 26 nCPM
proximal tubule cells: 25 nCPM
myosatellite cells: 22 nCPM
astrocytes: 20 nCPM
cone photoreceptor cells: 19 nCPM

Immune cell

naive CD8 T-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

white matter: 15 nTPM
midbrain: 11 nTPM
basal ganglia: 10 nTPM
cerebellum: 9.3 nTPM
cerebral cortex: 9.3 nTPM
thalamus: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRPV1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRPV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPV1 as an antibody target. Whether an autoantibody or antibody against TRPV1 could matter depends on whether native TRPV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPV1 is annotated at the cell surface, where native TRPV1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRPV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...