IFI35
Interferon-induced 35 kDa protein
Also known as: IFP35, IN35_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P80217
- Gene
- IFI35
- Ensembl
- ENSG00000068079
- Chromosome
- 17
- Canonical length
- 286 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of defense response. Located in several cellular components, including cytosol; extracellular space; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
286 residues, UniProt reviewed canonical sequence.
>P80217|IFI35
1 MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP
61 EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM
121 VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM
181 LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD
241 ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IFI35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 41 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 41 nTPM
- spleen: 39 nTPM
- choroid plexus: 38 nTPM
- ovary: 30 nTPM
- kidney: 30 nTPM
- small intestine: 30 nTPM
Single-cell type
- enterocytes: 117 nCPM
- hofbauer cells: 111 nCPM
- decidual stromal cells: 85 nCPM
- granulosa cells: 84 nCPM
- colonocytes: 73 nCPM
- schwann cells: 72 nCPM
Immune cell
- intermediate monocyte: 128 nTPM
- non-classical monocyte: 123 nTPM
- classical monocyte: 103 nTPM
- total PBMC: 81 nTPM
- plasmacytoid DC: 67 nTPM
- neutrophil: 62 nTPM
Brain region
- medulla oblongata: 21 nTPM
- spinal cord: 21 nTPM
- pons: 14 nTPM
- thalamus: 14 nTPM
- white matter: 13 nTPM
- hypothalamus: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.36
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- innate immune response
- macrophage activation involved in immune response
- negative regulation of cell population proliferation
- negative regulation of non-canonical NF-kappaB signal transduction
- positive regulation of inflammatory response
- positive regulation of innate immune response
- positive regulation of non-canonical NF-kappaB signal transduction
- positive regulation of toll-like receptor 4 signaling pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IFI35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IFI35 as an antibody target. Whether an autoantibody or antibody against IFI35 could matter depends on whether native IFI35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IFI35 is annotated as secreted, so native IFI35 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IFI35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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