Seroatlas · Human Serome Atlas

MAP3K9

Mitogen-activated protein kinase kinase kinase 9

Also known as: M3K9_HUMAN, MEKK9, MLK1, PRKE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80192
Gene: MAP3K9
Ensembl: ENSG00000006432
Chromosome: 14
Canonical length: 1104 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables molecular function activator activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1104 residues, UniProt reviewed canonical sequence.

>P80192|MAP3K9
     1  MEPSRALLGC LASAAAAAPP GEDGAGAGAE EEEEEEEEAA AAVGPGELGC DAPLPYWTAV
    61  FEYEAAGEDE LTLRLGDVVE VLSKDSQVSG DEGWWTGQLN QRVGIFPSNY VTPRSAFSSR
   121  CQPGGEDPSC YPPIQLLEID FAELTLEEII GIGGFGKVYR AFWIGDEVAV KAARHDPDED
   181  ISQTIENVRQ EAKLFAMLKH PNIIALRGVC LKEPNLCLVM EFARGGPLNR VLSGKRIPPD
   241  ILVNWAVQIA RGMNYLHDEA IVPIIHRDLK SSNILILQKV ENGDLSNKIL KITDFGLARE
   301  WHRTTKMSAA GTYAWMAPEV IRASMFSKGS DVWSYGVLLW ELLTGEVPFR GIDGLAVAYG
   361  VAMNKLALPI PSTCPEPFAK LMEDCWNPDP HSRPSFTNIL DQLTTIEESG FFEMPKDSFH
   421  CLQDNWKHEI QEMFDQLRAK EKELRTWEEE LTRAALQQKN QEELLRRREQ ELAEREIDIL
   481  ERELNIIIHQ LCQEKPRVKK RKGKFRKSRL KLKDGNRISL PSDFQHKFTV QASPTMDKRK
   541  SLINSRSSPP ASPTIIPRLR AIQLTPGESS KTWGRSSVVP KEEGEEEEKR APKKKGRTWG
   601  PGTLGQKELA SGDEGSPQRR EKANGLSTPS ESPHFHLGLK SLVDGYKQWS SSAPNLVKGP
   661  RSSPALPGFT SLMEMEDEDS EGPGSGESRL QHSPSQSYLC IPFPRGEDGD GPSSDGIHEE
   721  PTPVNSATST PQLTPTNSLK RGGAHHRRCE VALLGCGAVL AATGLGFDLL EAGKCQLLPL
   781  EEPEPPAREE KKRREGLFQR SSRPRRSTSP PSRKLFKKEE PMLLLGDPSA SLTLLSLSSI
   841  SECNSTRSLL RSDSDEIVVY EMPVSPVEAP PLSPCTHNPL VNVRVERFKR DPNQSLTPTH
   901  VTLTTPSQPS SHRRTPSDGA LKPETLLASR SPSSNGLSPS PGAGMLKTPS PSRDPGEFPR
   961  LPDPNVVFPP TPRRWNTQQD STLERPKTLE FLPRPRPSAN RQRLDPWWFV SPSHARSTSP
  1021  ANSSSTETPS NLDSCFASSS STVEERPGLP ALLPFQAGPL PPTERTLLDL DAEGQSQDST
  1081  VPLCRAELNT HRPAPYEIQQ EFWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
retina: 8.9 nTPM
cerebral cortex: 8.3 nTPM
esophagus: 8.2 nTPM
testis: 6.6 nTPM
hypothalamus: 5.3 nTPM

Single-cell type

esophageal apical cells: 267 nCPM
ocular epithelial cells: 90 nCPM
retinal ganglion cells: 73 nCPM
salivary basal cells: 62 nCPM
alveolar cells type 1: 62 nCPM
choroid plexus epithelial cells: 61 nCPM

Immune cell

naive B-cell: 0.3 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
T-reg: 0.2 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebral cortex: 79 nTPM
cerebellum: 53 nTPM
thalamus: 53 nTPM
pons: 50 nTPM
white matter: 46 nTPM
medulla oblongata: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.12
gnomAD missense Z: 1.27
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP3K9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP3K9 as an antibody target. Whether an autoantibody or antibody against MAP3K9 could matter depends on whether native MAP3K9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP3K9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP3K9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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