MYL12B
Myosin regulatory light chain 12B
Also known as: ML12B_HUMAN, MRLC2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14950
- Gene
- MYL12B
- Ensembl
- ENSG00000118680
- Chromosome
- 18
- Canonical length
- 172 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>O14950|MYL12B
1 MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS
61 LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE
121 DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYL12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 576 nTPM
Expression across tissuesHPA
Tissue
- kidney: 576 nTPM
- esophagus: 515 nTPM
- blood vessel: 462 nTPM
- epididymis: 456 nTPM
- adrenal gland: 447 nTPM
- lung: 441 nTPM
Single-cell type
- esophageal apical cells: 4,984 nCPM
- esophageal suprabasal cells: 1,895 nCPM
- syncytiotrophoblasts: 1,685 nCPM
- colonocytes: 1,526 nCPM
- extravillous trophoblasts: 1,435 nCPM
- migrating cytotrophoblasts: 1,366 nCPM
Immune cell
- eosinophil: 1,517 nTPM
- basophil: 1,490 nTPM
- total PBMC: 1,294 nTPM
- neutrophil: 1,147 nTPM
- non-classical monocyte: 802 nTPM
- plasmacytoid DC: 799 nTPM
Brain region
- choroid plexus: 157 nTPM
- hypothalamus: 113 nTPM
- medulla oblongata: 112 nTPM
- pons: 111 nTPM
- thalamus: 110 nTPM
- hippocampal formation: 109 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MYL12B.
Disease | ImmuneIEDB
Conditions an epitope on MYL12B was assayed in.
- pancreatic ductal adenocarcinoma T cell
- type 1 diabetes mellitus T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 1.74
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MYL12B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYL12B as an antibody target. Whether an autoantibody or antibody against MYL12B could matter depends on whether native MYL12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYL12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYL12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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