Seroatlas · Human Serome Atlas

SPATA6

Spermatogenesis-associated protein 6

Also known as: FLJ10007, SPAT6_HUMAN, SRF-1, SRF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWH7
Gene: SPATA6
Ensembl: ENSG00000132122
Chromosome: 1
Canonical length: 488 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable myosin light chain binding activity. Predicted to be involved in motile cilium assembly and spermatogenesis. Predicted to be located in extracellular region and motile cilium. Predicted to be active in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9NWH7|SPATA6
     1  MPKVKALQCA LALEISSVTC PGVVLKDKED IYLSICVFGQ YKKTQCVPAT FPLVFNARMV
    61  FEKVFPDAVD PGDVVTQLEY DTAVFELIQL VPPVGETLST YDENTRDFMF PGPNQMSGHH
   121  DSNRQVTMRR ISGLRGNAPR LEFSTTSVIT ECLISSRKCH TQDKFIYHLA PVEKSHGRLQ
   181  NRTSRSQKKK SKSPERSKYC INAKNYEQPT ISSKSHSPSP YTKRRMCELS EDTRRRLAHL
   241  NLGPYEFKKE TDKPPFVIRH VDPPSPRADT LLGSSGRDCE RDGWSRVHND HSHLGCCRPK
   301  DYKVIRTPHG RDFDDSLEKC EEYLSPRSCS KPRHSARTLL VHSAPSTMPK HSPSPVLNRA
   361  SLRERFHSDW CSPSNCDEIH DRVKNVLKSH QAHQRHLYDE RDLEKDDELE LKRSLLCRDS
   421  AYDSDPEYSS CQQPRGTFHL DDGEYWSNRA ASYKGKSHRP IFENSMDKMY RNLYKKACSS
   481  ASHTQESF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
fallopian tube: 14 nTPM
retina: 12 nTPM
parathyroid gland: 10 nTPM
thyroid gland: 8.9 nTPM
ovary: 8.5 nTPM

Single-cell type

late spermatids: 6,642 nCPM
early spermatids: 1,655 nCPM
oligodendrocyte progenitor cells: 660 nCPM
late primary spermatocytes: 548 nCPM
ependymal cells: 437 nCPM
bergmann glia: 429 nCPM

Immune cell

non-classical monocyte: 5.9 nTPM
eosinophil: 3.6 nTPM
intermediate monocyte: 2.8 nTPM
classical monocyte: 1.2 nTPM
myeloid DC: 1.1 nTPM
plasmacytoid DC: 0.5 nTPM

Brain region

white matter: 26 nTPM
basal ganglia: 21 nTPM
thalamus: 21 nTPM
medulla oblongata: 20 nTPM
midbrain: 19 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

myosin light chain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MYL6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA6 as an antibody target. Whether an autoantibody or antibody against SPATA6 could matter depends on whether native SPATA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA6 is annotated as secreted, so native SPATA6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPATA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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