Membrane-associated guanylate kinase
IPR050716
Definition
The MAGUK family proteins are multifunctional scaffolding proteins that play pivotal roles in cell polarity, tight junction biogenesis, and synaptic transmembrane protein anchoring. They are involved in various cellular processes including the regulation of neutrophil polarity, epithelial cell polarity, vascular lumen formation, and neuronal progenitor cell survival. These proteins are essential for the correct localization and trafficking of various cellular components, such as adherens junction proteins, myelin proteins, and vesicular markers. They also participate in signal transduction pathways, potentially influencing mTOR signaling and NF-kappa-B activation. Additionally, they have a role in the maintenance and organization of cerebellar progenitor cells and retinal development. The MAGUK family members contain characteristic domains such as PDZ, L27, and PRBH, which mediate their interactions with other proteins and membranes.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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