Seroatlas · Human Serome Atlas

LIN7A

Protein lin-7 homolog A

Also known as: LIN-7A, LIN7A_HUMAN, MALS-1, TIP-33, VELI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14910
Gene: LIN7A
Ensembl: ENSG00000111052
Chromosome: 12
Canonical length: 233 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>O14910|LIN7A
     1  MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL QSLKKVLQSE
    61  FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS EGHSHPRVVE LPKTDEGLGF
   121  NVMGGKEQNS PIYISRIIPG GVAERHGGLK RGDQLLSVNG VSVEGEHHEK AVELLKAAKD
   181  SVKLVVRYTP KVLEEMEARF EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 26 nTPM
retina: 25 nTPM
cerebellum: 19 nTPM
liver: 17 nTPM
kidney: 8.1 nTPM
endometrium: 7.9 nTPM

Single-cell type

neutrophils: 714 nCPM
neutrophil progenitors: 687 nCPM
retinal bipolar cells: 290 nCPM
bergmann glia: 258 nCPM
renal collecting duct intercalated cells: 253 nCPM
lactotrophs: 237 nCPM

Immune cell

neutrophil: 30 nTPM
basophil: 19 nTPM
eosinophil: 16 nTPM
classical monocyte: 5.2 nTPM
total PBMC: 1.2 nTPM
intermediate monocyte: 0.8 nTPM

Brain region

cerebellum: 53 nTPM
cerebral cortex: 23 nTPM
midbrain: 21 nTPM
thalamus: 21 nTPM
basal ganglia: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN7A as an antibody target. Whether an autoantibody or antibody against LIN7A could matter depends on whether native LIN7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN7A is annotated at the cell surface, where native LIN7A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIN7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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