CLIC3

Protein identityUniProt · HPA

UniProt accession

O95833

Gene

CLIC3

Ensembl

ENSG00000169583

Chromosome

9

Canonical length

236 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Nuclear bodies

OverviewNCBI Gene

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>O95833|CLIC3
     1  MAETKLQLFV KASEDGESVG HCPSCQRLFM VLLLKGVPFT LTTVDTRRSP DVLKDFAPGS
    61  QLPILLYDSD AKTDTLQIED FLEETLGPPD FPSLAPRYRE SNTAGNDVFH KFSAFIKNPV
   121  PAQDEALYQQ LLRALARLDS YLRAPLEHEL AGEPQLRESR RRFLDGDRLT LADCSLLPKL
   181  HIVDTVCAHF RQAPIPAELR GVRRYLDSAM QEKEFKYTCP HSAEILAAYR PAVHPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

435 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.89

gnomAD pLI

0

gnomAD missense Z

1.14

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chloride transport
• positive regulation of sprouting angiogenesis
• signal transduction

Molecular functions

• chloride channel activity
• protein-disulfide reductase (glutathione) activity

Cellular components

• chloride channel complex
• cytoplasm
• extracellular exosome
• extracellular matrix
• membrane
• nuclear body
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Intracellular chloride channel
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• CLIC, N-terminal domain
• Glutathione S-transferase, C-terminal domain
• CLIC-like N-terminal domain

KeywordsUniProt

• Cell membrane
• Chloride
• Chloride channel
• Cytoplasm
• Disulfide bond
• Extracellular matrix
• Ion channel
• Ion transport
• Membrane
• Nucleus
• Oxidoreductase
• Phosphoprotein
• Secreted
• Transmembrane
• Transmembrane helix
• Transport
• Voltage-gated channel

InteractionsUniProt · HPA

Protein binding partners of CLIC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPK15
• AGR2