Seroatlas · Human Serome Atlas

SIDT2

SID1 transmembrane family member 2

Also known as: CGI-40, SIDT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBJ9
Gene: SIDT2
Ensembl: ENSG00000149577
Chromosome: 11
Canonical length: 832 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Involved in RNA transport. Located in lysosomal membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

832 residues, UniProt reviewed canonical sequence.

>Q8NBJ9|SIDT2
     1  MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN
    61  RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GMFQRKYLYQ KVERTLCQPP
   121  TKNESEIQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE
   181  GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS
   241  NSFYVVVVVK TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
   301  LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG SSPYEGYNYG
   361  SFENVSGSTD GLVDSAGTGD LSYGYQGRSF EPVGTRPRVD SMSSVEEDDY DTLTDIDSDK
   421  NVIRTKQYLY VADLARKDKR VLRKKYQIYF WNIATIAVFY ALPVVQLVIT YQTVVNVTGN
   481  QDICYYNFLC AHPLGNLSAF NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLCALE
   541  CGIPKHFGLF YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP
   601  DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSII HIIATLLLST QLYYMGRWKL
   661  DSGIFRRILH VLYTDCIRQC SGPLYVDRMV LLVMGNVINW SLAAYGLIMR PNDFASYLLA
   721  IGICNLLLYF AFYIIMKLRS GERIKLIPLL CIVCTSVVWG FALFFFFQGL STWQKTPAES
   781  REHNRDCILL DFFDDHDIWH FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIDT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

pancreas: 109 nTPM
stomach: 71 nTPM
ovary: 59 nTPM
prostate: 47 nTPM
duodenum: 42 nTPM
small intestine: 40 nTPM

Single-cell type

pancreatic acinar cells: 97 nCPM
kupffer cells: 94 nCPM
goblet cells: 85 nCPM
foveolar cells: 69 nCPM
extravillous trophoblasts: 67 nCPM
adipocytes: 62 nCPM

Immune cell

non-classical monocyte: 152 nTPM
intermediate monocyte: 84 nTPM
naive B-cell: 21 nTPM
memory B-cell: 18 nTPM
classical monocyte: 14 nTPM
myeloid DC: 12 nTPM

Brain region

white matter: 91 nTPM
medulla oblongata: 70 nTPM
pons: 60 nTPM
spinal cord: 55 nTPM
midbrain: 53 nTPM
thalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 1.95
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

AP-1 adaptor complex binding
AP-2 adaptor complex binding
DNA binding
double-stranded RNA binding
RNA transmembrane transporter activity
nucleic acid transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIDT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LAMP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIDT2 as an antibody target. Whether an autoantibody or antibody against SIDT2 could matter depends on whether native SIDT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIDT2 is annotated at the cell surface, where native SIDT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIDT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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