SMCP
Sperm mitochondrial-associated cysteine-rich protein
Also known as: MCSP, MCSP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P49901
- Gene
- SMCP
- Ensembl
- ENSG00000163206
- Chromosome
- 1
- Canonical length
- 116 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>P49901|SMCP
1 MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC CPPKHNHCCQ
61 PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ TQQQPHSPQN ESRPSKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SMCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 717 nTPM
Expression across tissuesHPA
Tissue
- testis: 717 nTPM
- cerebellum: 1.2 nTPM
- cerebral cortex: 0.8 nTPM
- prostate: 0.6 nTPM
- breast: 0.5 nTPM
- basal ganglia: 0.4 nTPM
Single-cell type
- late spermatids: 24,930 nCPM
- early spermatids: 3,991 nCPM
- late primary spermatocytes: 1,426 nCPM
- sertoli cells: 40 nCPM
- leydig cells: 33 nCPM
- peritubular myoid cells: 18 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.6 nTPM
- hypothalamus: 0.2 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.14
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Sperm mitochondrial-associated cysteine-rich protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SMCP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SMCP as an antibody target. Whether an autoantibody or antibody against SMCP could matter depends on whether native SMCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SMCP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SMCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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