ZNF433
Zinc finger protein 433
Also known as: FLJ40981, ZN433_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N7K0
- Gene
- ZNF433
- Ensembl
- ENSG00000197647
- Chromosome
- 19
- Canonical length
- 673 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nuclear bodies
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
673 residues, UniProt reviewed canonical sequence.
>Q8N7K0|ZNF433
1 MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW KPQNIYVEYE
61 NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG VKSCESSVYG EVGSAHSSLN
121 RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP FNCLSSVQTH ERAHSGRKLY VCEECGKTFI
181 SHSNLQRHRI MHRGDGPYKC KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS
241 LRIHERTHTG EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
301 ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL TSFQNHLGMH
361 TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG KAFNSSSSFR YHERTHTGEK
421 PYECKQCGKA FRSASLLQTH GRTHTGEKPY ACKECGKPFS NFSFFQIHER MHREEKPYEC
481 KGYGKTFSLP SLFHRHERTH TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG
541 KAFRSASQLQ IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
601 CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ CGKVFRCSSQ
661 LQVHGRAHCI DTPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF433 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- testis: 20 nTPM
- kidney: 8.9 nTPM
- bone marrow: 6.9 nTPM
- retina: 6.8 nTPM
- epididymis: 6.4 nTPM
- pancreas: 6.3 nTPM
Single-cell type
- early spermatids: 205 nCPM
- late spermatids: 175 nCPM
- late primary spermatocytes: 140 nCPM
- oocytes: 46 nCPM
- esophageal apical cells: 29 nCPM
- epididymal principal cells: 27 nCPM
Immune cell
- basophil: 3.8 nTPM
- NK-cell: 3.5 nTPM
- myeloid DC: 3.3 nTPM
- plasmacytoid DC: 3 nTPM
- eosinophil: 2.5 nTPM
- naive B-cell: 1.9 nTPM
Brain region
- cerebellum: 26 nTPM
- hippocampal formation: 16 nTPM
- white matter: 16 nTPM
- medulla oblongata: 15 nTPM
- hypothalamus: 15 nTPM
- midbrain: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.4
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF433 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF433 as an antibody target. Whether an autoantibody or antibody against ZNF433 could matter depends on whether native ZNF433 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF433 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF433 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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