Seroatlas · Human Serome Atlas

TSNAX

Translin-associated protein X

Also known as: C3PO, TRAX, TSNAX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99598
Gene: TSNAX
Ensembl: ENSG00000116918
Chromosome: 1
Canonical length: 290 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q99598|TSNAX
     1  MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH DKYERLVKLS
    61  RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK IFQVAQELSG EDMHQFHRAI
   121  TTGLQEYVEA VSFQHFIKTR SLISMDEINK QLIFTTEDNG KENKTPSSDA QDKQFGTWRL
   181  RVTPVDYLLG VADLTGELMR MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS
   241  KKLYTLKQSL AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSNAX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 49 nTPM
tongue: 38 nTPM
parathyroid gland: 38 nTPM
adrenal gland: 30 nTPM
kidney: 30 nTPM
thyroid gland: 28 nTPM

Single-cell type

microglia: 82 nCPM
choroid plexus epithelial cells: 59 nCPM
oligodendrocytes: 55 nCPM
other brain neurons: 41 nCPM
brain excitatory neurons: 39 nCPM
bergmann glia: 37 nCPM

Immune cell

basophil: 195 nTPM
eosinophil: 86 nTPM
non-classical monocyte: 56 nTPM
NK-cell: 52 nTPM
intermediate monocyte: 40 nTPM
T-reg: 40 nTPM

Brain region

choroid plexus: 31 nTPM
hypothalamus: 25 nTPM
spinal cord: 21 nTPM
white matter: 21 nTPM
cerebral cortex: 20 nTPM
hippocampal formation: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.49
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.04
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSNAX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSNAX as an antibody target. Whether an autoantibody or antibody against TSNAX could matter depends on whether native TSNAX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSNAX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSNAX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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