Seroatlas · Human Serome Atlas

CROCC

Rootletin

Also known as: CROCC_HUMAN, CROCC1, ROLT, rootletin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TZA2
Gene
CROCC
Ensembl
ENSG00000058453
Chromosome
1
Canonical length
2017 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Primary cilium transition zone,Centrosome,Basal body,Mid piece

OverviewNCBI Gene

Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in several cellular components, including actin cytoskeleton; cytosol; and microtubule organizing center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2017 residues, UniProt reviewed canonical sequence.

>Q5TZA2|CROCC
     1  MSLGLAGAQE VELTLETVIQ TLESSVLCQE KGLGARDLAQ DAQITSLPAL IREIVTRNLS
    61  QPESPVLLPA TEMASLLSLQ EENQLLQQEL SRVEDLLAQS RAERDELAIK YNAVSERLEQ
   121  ALRLEPGELE TQEPRGLVRQ SVELRRQLQE EQASYRRKLQ AYQEGQQRQA QLVQRLQGKI
   181  LQYKKRCSEL EQQLLERSGE LEQQRLRDTE HSQDLESALI RLEEEQQRSA SLAQVNAMLR
   241  EQLDQAGSAN QALSEDIRKV TNDWTRCRKE LEHREAAWRR EEESFNAYFS NEHSRLLLLW
   301  RQVVGFRRLV SEVKMFTERD LLQLGGELAR TSRAVQEAGL GLSTGLRLAE SRAEAALEKQ
   361  ALLQAQLEEQ LRDKVLREKD LAQQQMQSDL DKADLSARVT ELGLAVKRLE KQNLEKDQVN
   421  KDLTEKLEAL ESLRLQEQAA LETEDGEGLQ QTLRDLAQAV LSDSESGVQL SGSERTADAS
   481  NGSLRGLSGQ RTPSPPRRSS PGRGRSPRRG PSPACSDSST LALIHSALHK RQLQVQDMRG
   541  RYEASQDLLG TLRKQLSDSE SERRALEEQL QRLRDKTDGA MQAHEDAQRE VQRLRSANEL
   601  LSREKSNLAH SLQVAQQQAE ELRQEREKLQ AAQEELRRQR DRLEEEQEDA VQDGARVRRE
   661  LERSHRQLEQ LEGKRSVLAK ELVEVREALS RATLQRDMLQ AEKAEVAEAL TKAEAGRVEL
   721  ELSMTKLRAE EASLQDSLSK LSALNESLAQ DKLDLNRLVA QLEEEKSALQ GRQRQAEQEA
   781  TVAREEQERL EELRLEQEVA RQGLEGSLRV AEQAQEALEQ QLPTLRHERS QLQEQLAQLS
   841  RQLSGREQEL EQARREAQRQ VEALERAARE KEALAKEHAG LAVQLVAAER EGRTLSEEAT
   901  RLRLEKEALE GSLFEVQRQL AQLEARREQL EAEGQALLLA KETLTGELAG LRQQIIATQE
   961  KASLDKELMA QKLVQAEREA QASLREQRAA HEEDLQRLQR EKEAAWRELE AERAQLQSQL
  1021  QREQEELLAR LEAEKEELSE EIAALQQERD EGLLLAESEK QQALSLKESE KTALSEKLMG
  1081  TRHSLATISL EMERQKRDAQ SRQEQDRSTV NALTSELRDL RAQREEAAAA HAQEVRRLQE
  1141  QARDLGKQRD SCLREAEELR TQLRLLEDAR DGLRRELLEA QRKLRESQEG REVQRQEAGE
  1201  LRRSLGEGAK EREALRRSNE ELRSAVKKAE SERISLKLAN EDKEQKLALL EEARTAVGKE
  1261  AGELRTGLQE VERSRLEARR ELQELRRQMK MLDSENTRLG RELAELQGRL ALGERAEKES
  1321  RRETLGLRQR LLKGEASLEV MRQELQVAQR KLQEQEGEFR TRERRLLGSL EEARGTEKQQ
  1381  LDHARGLELK LEAARAEAAE LGLRLSAAEG RAQGLEAELA RVEVQRRAAE AQLGGLRSAL
  1441  RRGLGLGRAP SPAPRPVPGS PARDAPAEGS GEGLNSPSTL ECSPGSQPPS PGPATSPASP
  1501  DLDPEAVRGA LREFLQELRS AQRERDELRT QTSALNRQLA EMEAERDSAT SRARQLQKAV
  1561  AESEEARRSV DGRLSGVQAE LALQEESVRR SERERRATLD QVATLERSLQ ATESELRASQ
  1621  EKISKMKANE TKLEGDKRRL KEVLDASESR TVKLELQRRS LEGELQRSRL GLSDREAQAQ
  1681  ALQDRVDSLQ RQVADSEVKA GTLQLTVERL NGALAKVEES EGALRDKVRG LTEALAQSSA
  1741  SLNSTRDKNL HLQKALTACE HDRQVLQERL DAARQALSEA RKQSSSLGEQ VQTLRGEVAD
  1801  LELQRVEAEG QLQQLREVLR QRQEGEAAAL NTVQKLQDER RLLQERLGSL QRALAQLEAE
  1861  KREVERSALR LEKDRVALRR TLDKVEREKL RSHEDTVRLS AEKGRLDRTL TGAELELAEA
  1921  QRQIQQLEAQ VVVLEQSHSP AQLEVDAQQQ QLELQQEVER LRSAQAQTER TLEARERAHR
  1981  QRVRGLEEQV STLKGQLQQE LRRSSAPFSP PSGPPEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CROCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 28 nTPM
  • fallopian tube: 18 nTPM
  • skin: 14 nTPM
  • cervix: 13 nTPM
  • ovary: 13 nTPM
  • endometrium: 11 nTPM

Single-cell type

  • rod photoreceptor cells: 330 nCPM
  • respiratory ciliated cells: 240 nCPM
  • ependymal cells: 213 nCPM
  • plasma cells: 162 nCPM
  • enterocytes: 162 nCPM
  • choroid plexus epithelial cells: 140 nCPM

Immune cell

  • MAIT T-cell: 0.5 nTPM
  • eosinophil: 0.4 nTPM
  • gdT-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • T-reg: 0.3 nTPM

Brain region

  • choroid plexus: 62 nTPM
  • midbrain: 26 nTPM
  • cerebellum: 22 nTPM
  • medulla oblongata: 22 nTPM
  • cerebral cortex: 16 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
-0.35
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CROCC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CROCC as an antibody target. Whether an autoantibody or antibody against CROCC could matter depends on whether native CROCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CROCC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CROCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CROCC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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