Seroatlas · Human Serome Atlas

IFIT1B

Protein IFIT1 homolog B

Also known as: bA149I23.6, IFIT1L, IFT1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T764
Gene: IFIT1B
Ensembl: ENSG00000204010
Chromosome: 10
Canonical length: 474 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q5T764|IFIT1B
     1  MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY NVGIHNLLAY
    61  VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN FAWVYYHMGR LAEAQTYLDK
   121  VENTCKKFAN PSRYRMECPE VDCEEGWALA KCGGKNYERA KTCFEKALEG NPENPEFNTG
   181  YAITVYRLDK FNTASGRNKA FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI
   241  EEALTSISSQ AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI
   301  QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY AEIGHHRKAE
   361  EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT HYLKGLKIEK MSHSREKLLN
   421  ALEKLAKRCI HQNVRVVESV SLLGLIHKLK GEVSDALLCY ERALRLAADL NPIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFIT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
placenta: 2.7 nTPM
spleen: 1.1 nTPM
liver: 0.1 nTPM
lung: 0.1 nTPM
tongue: 0.1 nTPM

Single-cell type

erythrocytes: 135 nCPM
epicardial cells: 6.8 nCPM
cardiomyocytes: 6.7 nCPM
retinal horizontal cells: 6 nCPM
pericytes: 2 nCPM
retinal amacrine cells: 1.4 nCPM

Immune cell

total PBMC: 0.2 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 1.4 nTPM
cerebellum: 1.3 nTPM
hypothalamus: 0.8 nTPM
cerebral cortex: 0.7 nTPM
hippocampal formation: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFIT1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IFIT3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFIT1B as an antibody target. Whether an autoantibody or antibody against IFIT1B could matter depends on whether native IFIT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFIT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFIT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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