Seroatlas · Human Serome Atlas

ADORA2A

Adenosine receptor A2a

Also known as: AA2AR_HUMAN, ADORA2, RDC8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29274
Gene
ADORA2A
Ensembl
ENSG00000128271
Chromosome
22
Canonical length
412 aa
Protein class
Cancer-related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>P29274|ADORA2A
     1  MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI
    61  PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR
   121  AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF
   181  NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG
   241  LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
   301  KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG
   361  YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADORA2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 109 nTPM
  • thymus: 50 nTPM
  • bone marrow: 38 nTPM
  • kidney: 20 nTPM
  • lymph node: 19 nTPM
  • spleen: 15 nTPM

Single-cell type

  • brain inhibitory neurons: 15 nCPM
  • pericytes: 3.9 nCPM
  • brain excitatory neurons: 1.9 nCPM
  • oligodendrocyte progenitor cells: 1.8 nCPM
  • other brain neurons: 1.7 nCPM
  • oligodendrocytes: 1.5 nCPM

Immune cell

  • T-reg: 54 nTPM
  • naive CD4 T-cell: 52 nTPM
  • MAIT T-cell: 47 nTPM
  • naive CD8 T-cell: 43 nTPM
  • memory CD8 T-cell: 39 nTPM
  • naive B-cell: 39 nTPM

Brain region

  • basal ganglia: 201 nTPM
  • thalamus: 27 nTPM
  • cerebral cortex: 17 nTPM
  • amygdala: 10 nTPM
  • hippocampal formation: 9.1 nTPM
  • cerebellum: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.6
gnomAD missense Z
1.52
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADORA2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADORA2A as an antibody target. Whether an autoantibody or antibody against ADORA2A could matter depends on whether native ADORA2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADORA2A is annotated at the cell surface, where native ADORA2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADORA2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADORA2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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