Seroatlas · Human Serome Atlas

TMEM161A

Transmembrane protein 161A

Also known as: FLJ20422, FLJ39645, T161A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX61
Gene: TMEM161A
Ensembl: ENSG00000064545
Chromosome: 19
Canonical length: 479 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9NX61|TMEM161A
     1  MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA LAGKPRPRGR
    61  KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF LEYQWFVDFA VYSGGVYLFT
   121  EAYYYMLGPA KETNIAVFWC LLTVTFSIKM FLTVTRLYFS AEEGGERSVC LTFAFLFLLL
   181  AMLVQVVREE TLELGLEPGL ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA
   241  FLTFPGLRLA QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE
   301  TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR EAGRIEAREI
   361  QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW GLGPAPLLSP DPSSASAAPI
   421  GSGEDEVQQT AARIAGALGG LLTPLFLRGV LAYLIWWTAA CQLLASLFGL YFHQHLAGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM161A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 30 nTPM
liver: 16 nTPM
endometrium: 13 nTPM
parathyroid gland: 13 nTPM
adrenal gland: 13 nTPM
tongue: 12 nTPM

Single-cell type

myonuclei: 59 nCPM
decidual stromal cells: 50 nCPM
retinal pigment epithelial cells: 47 nCPM
oocytes: 32 nCPM
hepatocytes: 31 nCPM
ovarian stromal cells: 31 nCPM

Immune cell

plasmacytoid DC: 19 nTPM
T-reg: 11 nTPM
naive CD4 T-cell: 8.8 nTPM
myeloid DC: 8.5 nTPM
gdT-cell: 8.2 nTPM
memory CD4 T-cell: 7.5 nTPM

Brain region

choroid plexus: 16 nTPM
medulla oblongata: 15 nTPM
white matter: 13 nTPM
thalamus: 12 nTPM
pons: 12 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM161A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM161A as an antibody target. Whether an autoantibody or antibody against TMEM161A could matter depends on whether native TMEM161A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM161A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM161A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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