Seroatlas · Human Serome Atlas

YIF1B

Protein YIF1B

Also known as: FinGER8, YIF1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5BJH7
Gene
YIF1B
Ensembl
ENSG00000167645
Chromosome
19
Canonical length
314 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q5BJH7|YIF1B
     1  MHPAGLAAAA AGTPRLRKWP SKRRIPVSQP GMADPHQLFD DTSSAQSRGY GAQRAPGGLS
    61  YPAASPTPHA AFLADPVSNM AMAYGSSLAA QGKELVDKNI DRFIPITKLK YYFAVDTMYV
   121  GRKLGLLFFP YLHQDWEVQY QQDTPVAPRF DVNAPDLYIP AMAFITYVLV AGLALGTQDR
   181  FSPDLLGLQA SSALAWLTLE VLAILLSLYL VTVNTDLTTI DLVAFLGYKY VGMIGGVLMG
   241  LLFGKIGYYL VLGWCCVAIF VFMIRTLRLK ILADAAAEGV PVRGARNQLR MYLTMAVAAA
   301  QPMLMYWLTF HLVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YIF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 65 nTPM
  • liver: 54 nTPM
  • spinal cord: 51 nTPM
  • spleen: 46 nTPM
  • cerebral cortex: 43 nTPM
  • choroid plexus: 42 nTPM

Single-cell type

  • platelets: 253 nCPM
  • megakaryocytes: 148 nCPM
  • hofbauer cells: 116 nCPM
  • extravillous trophoblasts: 67 nCPM
  • megakaryocyte progenitors: 67 nCPM
  • esophageal suprabasal cells: 67 nCPM

Immune cell

  • myeloid DC: 301 nTPM
  • eosinophil: 180 nTPM
  • classical monocyte: 156 nTPM
  • plasmacytoid DC: 127 nTPM
  • total PBMC: 120 nTPM
  • intermediate monocyte: 120 nTPM

Brain region

  • white matter: 55 nTPM
  • pons: 54 nTPM
  • cerebellum: 51 nTPM
  • medulla oblongata: 50 nTPM
  • thalamus: 46 nTPM
  • spinal cord: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YIF1B.

Disease | AllUniProt

Conditions YIF1B is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
1.4
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YIF1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YIF1B as an antibody target. Whether an autoantibody or antibody against YIF1B could matter depends on whether native YIF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YIF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YIF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YIF1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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