YIF1A
Protein YIF1A
Also known as: 54TM, FinGER7, YIF1, YIF1A_HUMAN, YIF1P
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95070
- Gene
- YIF1A
- Ensembl
- ENSG00000174851
- Chromosome
- 11
- Canonical length
- 293 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus,Vesicles
OverviewNCBI Gene
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
293 residues, UniProt reviewed canonical sequence.
>O95070|YIF1A
1 MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS VNHLLGDPMA
61 NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA YVAKKLGLLV FPYTHQNWEV
121 QYSRDAPLPP RQDLNAPDLY IPTMAFITYV LLAGMALGIQ KRFSPEVLGL CASTALVWVV
181 MEVLALLLGL YLATVRSDLS TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA
241 LMYFIVRSLR TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YIF1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 146 nTPM
Expression across tissuesHPA
Tissue
- liver: 146 nTPM
- skeletal muscle: 95 nTPM
- pancreas: 85 nTPM
- pituitary gland: 73 nTPM
- choroid plexus: 73 nTPM
- blood vessel: 67 nTPM
Single-cell type
- extravillous trophoblasts: 345 nCPM
- decidual stromal cells: 202 nCPM
- hepatocytes: 192 nCPM
- enterocytes: 180 nCPM
- esophageal suprabasal cells: 179 nCPM
- syncytiotrophoblasts: 179 nCPM
Immune cell
- plasmacytoid DC: 142 nTPM
- intermediate monocyte: 142 nTPM
- non-classical monocyte: 141 nTPM
- myeloid DC: 117 nTPM
- total PBMC: 100 nTPM
- memory B-cell: 96 nTPM
Brain region
- choroid plexus: 46 nTPM
- white matter: 44 nTPM
- medulla oblongata: 39 nTPM
- spinal cord: 38 nTPM
- cerebellum: 38 nTPM
- pons: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.39
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of YIF1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YIF1A as an antibody target. Whether an autoantibody or antibody against YIF1A could matter depends on whether native YIF1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YIF1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YIF1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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