Seroatlas · Human Serome Atlas

TTYH1

Protein tweety homolog 1

Also known as: TTYH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H313
Gene
TTYH1
Ensembl
ENSG00000167614
Chromosome
19
Canonical length
450 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9H313|TTYH1
     1  MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SVFAPQEQEY QQALLLVAAL AGLGLGLSLI
    61  FIAVYLIRFC CCRPPEPPGS KIPSPGGGCV TWSCIVALLA GCTGIGIGFY GNSETSDGVS
   121  QLSSALLHAN HTLSTIDHLV LETVERLGEA VRTELTTLEE VLEPRTELVA AARGARRQAE
   181  AAAQQLQGLA FWQGVPLSPL QVAENVSFVE EYRWLAYVLL LLLELLVCLF TLLGLAKQSK
   241  WLVIVMTVMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDP YVLNLTQEET GLSSDILSYY
   301  LLCNRAVSNP FQQRLTLSQR ALANIHSQLL GLEREAVPQF PSAQKPLLSL EETLNVTEGN
   361  FHQLVALLHC RSLHKDYGAA LRGLCEDALE GLLFLLLFSL LSAGALATAL CSLPRAWALF
   421  PPSDDYDDTD DDDPFNPQES KRFVQWQSSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTYH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
419 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 419 nTPM
  • amygdala: 378 nTPM
  • cerebral cortex: 340 nTPM
  • midbrain: 298 nTPM
  • hippocampal formation: 237 nTPM
  • spinal cord: 221 nTPM

Single-cell type

  • astrocytes: 426 nCPM
  • bergmann glia: 398 nCPM
  • oligodendrocytes: 162 nCPM
  • oligodendrocyte progenitor cells: 109 nCPM
  • ependymal cells: 95 nCPM
  • fallopian secretory cells: 27 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 84 nTPM
  • spinal cord: 79 nTPM
  • basal ganglia: 77 nTPM
  • medulla oblongata: 76 nTPM
  • white matter: 75 nTPM
  • midbrain: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
0.38
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTYH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTYH1 as an antibody target. Whether an autoantibody or antibody against TTYH1 could matter depends on whether native TTYH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTYH1 is annotated at the cell surface, where native TTYH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TTYH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTYH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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