Seroatlas · Human Serome Atlas

GPRIN2

G protein-regulated inducer of neurite outgrowth 2

Also known as: GRIN2_HUMAN, KIAA0514, MGC15171

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60269
Gene: GPRIN2
Ensembl: ENSG00000204175
Chromosome: 10
Canonical length: 458 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Microtubules,Cytokinetic bridge,Mitotic spindle

OverviewNCBI Gene

Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>O60269|GPRIN2
     1  MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA QLGEASTRPQ
    61  APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST MGGSDLCRLR APSAAAMQRS
   121  HSDLVRSTQM RGHSGARKAS LSCSALGSSP VHRAQLQPGG TSGQGGQAPA GLERDLAPED
   181  ETSNSAWMLG ASQLSVPPLD LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE
   241  VRAGGCCHAL PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA
   301  GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT SPSLEAPAAL
   361  HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL EVLGVAIQKH LEMQFEQLQR
   421  APASEDSLSV EGRRGPLRAV MQSLRRPSCC GCSGAAPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skin: 14 nTPM
cerebellum: 9.1 nTPM
lung: 7.4 nTPM
small intestine: 5.9 nTPM
rectum: 4.7 nTPM
hypothalamus: 4.6 nTPM

Single-cell type

alveolar cells type 1: 50 nCPM
goblet cells: 48 nCPM
late spermatids: 29 nCPM
paneth cells: 27 nCPM
colonocytes: 20 nCPM
enterocytes: 19 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 23 nTPM
cerebellum: 21 nTPM
pons: 17 nTPM
thalamus: 14 nTPM
midbrain: 14 nTPM
medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuron projection development

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of GPRIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRIN2 as an antibody target. Whether an autoantibody or antibody against GPRIN2 could matter depends on whether native GPRIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRIN2 is annotated at the cell surface, where native GPRIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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