RGS10

Protein identityUniProt · HPA

UniProt accession

O43665

Gene

RGS10

Ensembl

ENSG00000148908

Chromosome

10

Canonical length

181 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>O43665|RGS10
     1  MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ SLKSTAKWAA SLENLLEDPE GVKRFREFLK
    61  KEFSEENVLF WLACEDFKKM QDKTQMQEKA KEIYMTFLSS KASSQVNVEG QSRLNEKILE
   121  EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKHKRTEE EEEDLPDAQT AAKRASRIYN
   181  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

207 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.52

gnomAD pLI

0.76

gnomAD missense Z

1.33

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled acetylcholine receptor signaling pathway
• G protein-coupled receptor signaling pathway
• negative regulation of signal transduction
• positive regulation of GTPase activity
• regulation of G protein-coupled receptor signaling pathway

Molecular functions

• G-protein alpha-subunit binding
• GTPase activator activity
• GTPase activity

Cellular components

• cytosol
• nuclear body
• nucleoplasm
• nucleus
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• RGS domain
• RGS, subdomain 1/3
• RGS domain superfamily
• RGS, subdomain 2
• Regulator of G-protein signaling 10/12/14-like
• Regulator of G protein signaling domain
• RGS10, RGS domain

KeywordsUniProt

• Cytoplasm
• GTPase activation
• Lipoprotein
• Nucleus
• Palmitate
• Phosphoprotein
• Signal transduction inhibitor

InteractionsUniProt · HPA

Protein binding partners of RGS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GNAI1
• GNAI3
• GNAZ