Seroatlas · Human Serome Atlas

LPAR1

Lysophosphatidic acid receptor 1

Also known as: edg-2, EDG2, Gpcr26, LPA1, LPAR1_HUMAN, Mrec1.3, rec.1.3, vzg-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92633
Gene
LPAR1
Ensembl
ENSG00000198121
Chromosome
9
Canonical length
364 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q92633|LPAR1
     1  MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK LVMGLGITVC
    61  IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST
   121  WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA
   181  IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS
   241  RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
   301  EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH TILAGVHSND
   361  HSVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
220 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 220 nTPM
  • midbrain: 185 nTPM
  • basal ganglia: 172 nTPM
  • hippocampal formation: 156 nTPM
  • amygdala: 155 nTPM
  • hypothalamus: 94 nTPM

Single-cell type

  • oligodendrocytes: 856 nCPM
  • fibro-adipogenic progenitors: 448 nCPM
  • schwann cells: 412 nCPM
  • microglia: 360 nCPM
  • fibroblasts: 347 nCPM
  • pituicytes/fscs: 255 nCPM

Immune cell

  • eosinophil: 18 nTPM
  • classical monocyte: 8.7 nTPM
  • intermediate monocyte: 2.9 nTPM
  • myeloid DC: 2.1 nTPM
  • NK-cell: 2.1 nTPM
  • total PBMC: 2.1 nTPM

Brain region

  • white matter: 506 nTPM
  • basal ganglia: 419 nTPM
  • medulla oblongata: 396 nTPM
  • midbrain: 350 nTPM
  • thalamus: 325 nTPM
  • amygdala: 297 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.19
gnomAD missense Z
2.42
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LPAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPAR1 as an antibody target. Whether an autoantibody or antibody against LPAR1 could matter depends on whether native LPAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPAR1 is annotated at the cell surface, where native LPAR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPAR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...