Seroatlas · Human Serome Atlas

GPR174

Probable G-protein coupled receptor 174

Also known as: FKSG79, GP174_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXC1
Gene
GPR174
Ensembl
ENSG00000147138
Chromosome
X
Canonical length
333 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Centriolar satellite

OverviewNCBI Gene

This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q9BXC1|GPR174
     1  MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE TKRAVIFMIN
    61  LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV NMYASIYFLV CISVRRFWFL
   121  MYPFRFHDCK QKYDLYISIA GWLIICLACV LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA
   181  QSVVMMTIGE LIGFVTPLLI VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL
   241  ICFAPYHFSF PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR
   301  RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR174 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 16 nTPM
  • lymph node: 14 nTPM
  • tonsil: 9.8 nTPM
  • spleen: 7.7 nTPM
  • appendix: 6.5 nTPM
  • small intestine: 3.4 nTPM

Single-cell type

  • t-cells: 105 nCPM
  • nk-cells: 72 nCPM
  • thymocytes: 39 nCPM
  • b-cells: 34 nCPM
  • innate lymphoid cells: 27 nCPM
  • pdcs: 18 nCPM

Immune cell

  • basophil: 6.8 nTPM
  • memory CD8 T-cell: 6 nTPM
  • non-classical monocyte: 5.5 nTPM
  • naive CD8 T-cell: 4.9 nTPM
  • memory CD4 T-cell: 4.8 nTPM
  • T-reg: 4.8 nTPM

Brain region

  • cerebellum: 2.4 nTPM
  • medulla oblongata: 2.4 nTPM
  • pons: 2.3 nTPM
  • cerebral cortex: 2 nTPM
  • amygdala: 1.9 nTPM
  • midbrain: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.4
gnomAD missense Z
0.65
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR174 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR174 as an antibody target. Whether an autoantibody or antibody against GPR174 could matter depends on whether native GPR174 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR174 is annotated at the cell surface, where native GPR174 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR174 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR174. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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