Seroatlas · Human Serome Atlas

RGS22

Regulator of G-protein signaling 22

Also known as: CT145, DKFZP434I092, PRTD-NY2, RGS22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE09
Gene: RGS22
Ensembl: ENSG00000132554
Chromosome: 8
Canonical length: 1264 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Actin filaments,Cytosol

OverviewNCBI Gene

Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1264 residues, UniProt reviewed canonical sequence.

>Q8NE09|RGS22
     1  MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD YGVFEVANDA
    61  PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP DEDETINVNY NIMCLSREEG
   121  IKWIKKERLP AFLESDCYFE YRLAKLVSQV RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA
   181  TEEDNLVIMK KFYVSLGEAS YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV
   241  SENFIFDDGV HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD
   301  VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK VSFDDCFESI
   361  HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW CISHRTYDIG NRKEFERFKK
   421  FIKGTLGERY WWLWMDIERL KVLKDPGRHQ RHLEKMKKCY LVSNGDYYLS AEILSKFKLL
   481  DGSQWNEEHL RNIQSEVLKP LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP
   541  FPQMATLLPL RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS
   601  KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV SDVGALGGSD
   661  MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL QAYHQLFYQE TLQPFKVCKQ
   721  AQYLFATYVA PSATLDIGLQ QEKKKEIYMK IQPPFEDLFD TAEEYILLLL LEPWTKMVKS
   781  DQIAYKKVEL VEETRQLDST YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY
   841  WDNVPAEYKH FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK
   901  AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV LVEIQKHVQN
   961  RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK KIGVWKPVES KWISSSCKII
  1021  AFRKALLNPV TSRQFQRFVA LKGDLLENGL LFWQEVQKYK DLCHSHCDES VIQKKITTII
  1081  NCFINSSIPP ALQIDIPVEQ AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN
  1141  LTDENIMSVL ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ
  1201  PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST MSLKKNMSAH
  1261  SSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

testis: 57 nTPM
fallopian tube: 10 nTPM
choroid plexus: 6.2 nTPM
ovary: 5.2 nTPM
endometrium: 2.7 nTPM
adipose tissue: 2.6 nTPM

Single-cell type

late spermatids: 2,835 nCPM
early spermatids: 756 nCPM
ependymal cells: 527 nCPM
leydig cells: 433 nCPM
respiratory ciliated cells: 417 nCPM
late primary spermatocytes: 332 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 24 nTPM
midbrain: 18 nTPM
medulla oblongata: 15 nTPM
hypothalamus: 13 nTPM
spinal cord: 9.9 nTPM
white matter: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of signal transduction

Molecular functions

G-protein alpha-subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RGS domain
RGS domain superfamily
RGS, subdomain 2
Regulator of G protein signaling domain
Regulator of G-protein signaling 22
Regulator of G-protein signaling 22, third RGS domain
Regulator of G protein signaling domain 22, fourth RGS domain
Regulator of G protein signaling domain 22, second RGS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS22 as an antibody target. Whether an autoantibody or antibody against RGS22 could matter depends on whether native RGS22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGS22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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