Seroatlas · Human Serome Atlas

TULP3

Tubby-related protein 3

Also known as: TUBL3, TULP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75386
Gene
TULP3
Ensembl
ENSG00000078246
Chromosome
12
Canonical length
442 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Plasma membrane,Primary cilium,Primary cilium transition zone,Basal body
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>O75386|TULP3
     1  MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA
    61  KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS
   121  KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN
   181  LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK
   241  RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR
   301  QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE
   361  LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY
   421  PLCAVQAFGI GLSSFDSKLA CE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TULP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 34 nTPM
  • cervix: 30 nTPM
  • blood vessel: 25 nTPM
  • skin: 24 nTPM
  • vagina: 23 nTPM
  • fallopian tube: 23 nTPM

Single-cell type

  • retinal horizontal cells: 180 nCPM
  • esophageal apical cells: 134 nCPM
  • müller glia: 125 nCPM
  • differentiating spermatogonia: 117 nCPM
  • fibro-adipogenic progenitors: 113 nCPM
  • ovarian stromal cells: 108 nCPM

Immune cell

  • MAIT T-cell: 3.5 nTPM
  • T-reg: 3.3 nTPM
  • naive CD8 T-cell: 2.8 nTPM
  • NK-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • gdT-cell: 2.1 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 20 nTPM
  • medulla oblongata: 20 nTPM
  • choroid plexus: 19 nTPM
  • midbrain: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TULP3.

Disease | AllUniProt

Conditions TULP3 is implicated in, by any mechanism.

  • Hepatorenocardiac degenerative fibrosis (HRCDF) MIM:619902

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TULP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TULP3 as an antibody target. Whether an autoantibody or antibody against TULP3 could matter depends on whether native TULP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TULP3 is annotated at the cell surface, where native TULP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TULP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TULP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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