Seroatlas · Human Serome Atlas

TARM1

T-cell-interacting, activating receptor on myeloid cells protein 1

Also known as: TARM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B6A8C7
Gene: TARM1
Ensembl: ENSG00000248385
Chromosome: 19
Canonical length: 271 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>B6A8C7|TARM1
     1  MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW TPARGVSFVL
    61  RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY RKASPHILSQ HSDVLLLLVT
   121  GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID
   181  FSLVDVTAGD AGNYSCMYYQ TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA
   241  AVIVVIMGAF LVEAWYSRNV SPGESEAFKP E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TARM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 6.6 nTPM
spleen: 0.3 nTPM
gallbladder: 0.1 nTPM
retina: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

neutrophil progenitors: 3.7 nCPM
distal convoluted tubule cells: 0.6 nCPM
bergmann glia: 0.2 nCPM
loop of henle epithelial cells: 0.2 nCPM
microglia: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 0.7 nTPM
classical monocyte: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
total PBMC: 0.2 nTPM
eosinophil: 0.1 nTPM

Brain region

white matter: 2.5 nTPM
choroid plexus: 2 nTPM
cerebellum: 1.9 nTPM
cerebral cortex: 1.7 nTPM
pons: 1.7 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

immunoglobulin receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TARM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FCER1G

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TARM1 as an antibody target. Whether an autoantibody or antibody against TARM1 could matter depends on whether native TARM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TARM1 is annotated at the cell surface, where native TARM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TARM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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