LILRA4

Protein identityUniProt · HPA

UniProt accession

P59901

Gene

LILRA4

Ensembl

ENSG00000239961

Chromosome

19

Canonical length

499 aa

Protein class

CD markers, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>P59901|LILRA4
     1  MTLILTSLLF FGLSLGPRTR VQAENLLKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL
    61  DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY
   121  SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF
   181  PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL
   241  TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN
   301  VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA
   361  AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA
   421  TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE
   481  ANSRKDNAPF RVVEPWEQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

10 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.45

gnomAD pLI

0

gnomAD missense Z

-0.5

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytokine-mediated signaling pathway
• Fc-epsilon receptor signaling pathway
• immune response-regulating signaling pathway
• innate immune response
• negative regulation of interferon-alpha production
• negative regulation of toll-like receptor 9 signaling pathway
• negative regulation of tumor necrosis factor production
• negative regulation of toll-like receptor 7 signaling pathway

Molecular functions

• coreceptor activity
• inhibitory MHC class I receptor activity
• signaling receptor binding

Cellular components

• Fc-epsilon receptor I complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin-like beta-sandwich domain
• Immunoglobulin-like fold
• Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor
• Immunoglobulin-like domain superfamily
• Immunoglobulin-like Receptors in Immune Regulation
• Immunoglobulin domain
• Immunoglobulin domain
• Immunoglobulin domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Innate immunity
• Membrane
• Nitration
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LILRA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BST2
• FCER1G