FGB

Protein identityUniProt · HPA

UniProt accession

P02675

Gene

FGB

Ensembl

ENSG00000171564

Chromosome

4

Canonical length

491 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Endoplasmic reticulum

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>P02675|FGB
     1  MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR
    61  PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE
   121  RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ
   181  LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE
   241  CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK
   301  QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT
   361  VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP
   421  RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM
   481  SMKIRPFFPQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

16,765 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGB.

Disease | AllUniProt

Conditions FGB is implicated in, by any mechanism.

• Congenital afibrinogenemia (CAFBN) MIM:202400
• Dysfibrinogenemia, congenital (DYSFIBRIN) MIM:616004

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 268 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital afibrinogenemia
• Familial dysfibrinogenemia
• FGB-related disorder
• Hypofibrinogenemia
• See cases

Disease | ImmuneIEDB

Conditions an epitope on FGB was assayed in.

• rheumatoid arthritis B and T cell
• myocardial infarction T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.57

gnomAD missense Z

0.73

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• blood coagulation, fibrin clot formation
• cell-matrix adhesion
• cellular response to interleukin-1
• cellular response to leptin stimulus
• fibrinolysis
• induction of bacterial agglutination
• innate immune response
• negative regulation of endothelial cell apoptotic process
• negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
• plasminogen activation
• platelet aggregation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of exocytosis
• positive regulation of heterotypic cell-cell adhesion
• positive regulation of peptide hormone secretion
• positive regulation of protein secretion
• positive regulation of substrate adhesion-dependent cell spreading
• positive regulation of vasoconstriction
• protein polymerization
• protein-containing complex assembly
• response to calcium ion

Molecular functions

• extracellular matrix structural constituent
• protein-folding chaperone binding
• signaling receptor binding
• structural molecule activity

Cellular components

• blood microparticle
• cell cortex
• cell surface
• endoplasmic reticulum
• external side of plasma membrane
• extracellular exosome
• extracellular matrix
• extracellular region
• extracellular space
• extracellular vesicle
• fibrinogen complex
• plasma membrane
• platelet alpha granule
• platelet alpha granule lumen
• synapse

Protein domainsUniProt · Pfam · InterPro

• Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
• Fibrinogen, alpha/beta/gamma chain, coiled coil domain
• Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
• Fibrinogen, conserved site
• Fibrinogen-like, C-terminal
• Fibrinogen/angiopoietin-like
• Fibrinogen beta and gamma chains, C-terminal globular domain
• Fibrinogen alpha/beta chain family

KeywordsUniProt

• Adaptive immunity
• Blood coagulation
• Coiled coil
• Disulfide bond
• Glycoprotein
• Hemostasis
• Immunity
• Innate immunity
• Pyrrolidone carboxylic acid
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of FGB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBLN1
• FGA