Seroatlas · Human Serome Atlas

HBEGF

Proheparin-binding EGF-like growth factor

Also known as: DTR, DTS, HBEGF_HUMAN, HEGFL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99075
Gene
HBEGF
Ensembl
ENSG00000113070
Chromosome
5
Canonical length
208 aa
Protein class
Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

Enables growth factor activity; heparin binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of wound healing. Located in cell surface. Is active in extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q99075|HBEGF
     1  MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK
    61  VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE
   121  CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG
   181  LLMFRYHRRG GYDVENEEKV KLGMTNSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HBEGF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 120 nTPM
  • adipose tissue: 67 nTPM
  • gallbladder: 53 nTPM
  • lung: 43 nTPM
  • esophagus: 42 nTPM
  • bone marrow: 34 nTPM

Single-cell type

  • esophageal apical cells: 538 nCPM
  • ocular epithelial cells: 487 nCPM
  • epididymal basal cells: 465 nCPM
  • esophageal suprabasal cells: 444 nCPM
  • urothelial cells: 295 nCPM
  • monocytes: 289 nCPM

Immune cell

  • intermediate monocyte: 2.2 nTPM
  • myeloid DC: 1.6 nTPM
  • non-classical monocyte: 1.6 nTPM
  • classical monocyte: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • white matter: 20 nTPM
  • medulla oblongata: 17 nTPM
  • spinal cord: 17 nTPM
  • pons: 15 nTPM
  • thalamus: 15 nTPM
  • basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0.08
gnomAD missense Z
1.36
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HBEGF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HBEGF as an antibody target. Whether an autoantibody or antibody against HBEGF could matter depends on whether native HBEGF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HBEGF is annotated at the cell surface, where native HBEGF is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HBEGF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HBEGF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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