Nephronectin domain-containing protein
IPR052235
Definition
This family of proteins is involved in the regulation of kidney development and organ morphogenesis. Members of this family are known to interact with integrin alpha-8/beta-1, serving as functional ligands that regulate the expression of growth factors essential for these developmental processes. They also play roles in cell adhesion, spreading, and survival by binding to various integrins. Additionally, these proteins contribute to matrix assembly and may influence hair follicle morphogenesis. The presence of a MAM domain in some family members is critical for their localization at the cell surface, indicating a role in cell-matrix interactions.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...