SNTG2

Protein identityUniProt · HPA

UniProt accession

Q9NY99

Gene

SNTG2

Ensembl

ENSG00000172554

Chromosome

2

Canonical length

539 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q9NY99|SNTG2
     1  MGTEGPPPPA ASRGRQGCLL VPARTKTTIA LLYDEESENA YDIRLKLTKE VLTIQKQDVV
    61  CVGGSHQGRN RRTVTLRRQP VGGLGLSIKG GSEHNVPVVI SKIFEDQAAD QTGMLFVGDA
   121  VLQVNGIHVE NATHEEVVHL LRNAGDEVTI TVEYLREAPA FLKLPLGSPG PSSDHSSGAS
   181  SPLFDSGLHL NGNSSTTAPS SPSSPIAKDP RYEKRWLDTL SVPLSMARIS RYKAGTEKLR
   241  WNAFEVLALD GVSSGILRFY TAQDGTDWLR AVSANIRELT LQNMKMANKC CSPSDQVVHM
   301  GWVNEKLQGA DSSQTFRPKF LALKGPSFYV FSTPPVSTFD WVRAERTYHL CEVLFKVHKF
   361  WLTEDCWLQA NLYLGLQDFD FEDQRPYCFS IVAGHGKSHV FNVELGSELA MWEKSFQRAT
   421  FMEVQRTGSR TYMCSWQGEM LCFTVDFALG FTCFESKTKN VLWRFKFSQL KGSSDDGKTR
   481  VKLLFQNLDT KQIETKELEF QDLRAVLHCI HSFIAAKVAS VDPGFMDSQS LARKYMYSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNTG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

3.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

-0.19

DepMap mean gene effect

0.16

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• central nervous system development

Molecular functions

• actin binding
• neuroligin family protein binding
• PDZ domain binding
• structural molecule activity

Cellular components

• cytoskeleton
• dystrophin-associated glycoprotein complex
• nucleoplasm
• plasma membrane
• sarcolemma
• syntrophin complex

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• Syntrophin
• PDZ superfamily
• Syntrophin, C-terminal PH domain
• PDZ domain
• Syntrophin C-terminal PH domain

KeywordsUniProt

• Actin-binding
• Cell membrane
• Cytoplasm
• Cytoskeleton
• Membrane

InteractionsUniProt · HPA

Protein binding partners of SNTG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DTNB
• DMD
• DTNA