Seroatlas · Human Serome Atlas

SNTB2

Beta-2-syntrophin

Also known as: D16S2531E, EST25263, SNT2B2, SNT3, SNTB2_HUMAN, SNTL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13425
Gene
SNTB2
Ensembl
ENSG00000168807
Chromosome
16
Canonical length
540 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane,Primary cilium transition zone,Centriolar satellite,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q13425|SNTB2
     1  MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL TGDAAAAELE
    61  PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP RGPAGEAGAS PPVRRVRVVK
   121  QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD LRQATHDQAV
   181  QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST
   241  KDRKIIPLKM CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM
   301  ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY
   361  DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE
   421  THRDLSSWTR ILVQGCHAAA ELIKEVSLGC MLNGQEVRLT IHYENGFTIS RENGGSSSIL
   481  YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNTB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • retina: 20 nTPM
  • parathyroid gland: 12 nTPM
  • adipose tissue: 10 nTPM
  • endometrium: 10 nTPM
  • thyroid gland: 9.9 nTPM
  • cervix: 9.4 nTPM

Single-cell type

  • müller glia: 272 nCPM
  • choroid plexus epithelial cells: 208 nCPM
  • rod photoreceptor cells: 177 nCPM
  • smooth muscle cells: 161 nCPM
  • adipocytes: 140 nCPM
  • lymphatic endothelial cells: 139 nCPM

Immune cell

  • naive CD8 T-cell: 1.1 nTPM
  • gdT-cell: 0.9 nTPM
  • MAIT T-cell: 0.9 nTPM
  • neutrophil: 0.8 nTPM
  • NK-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.5 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • cerebral cortex: 22 nTPM
  • white matter: 16 nTPM
  • amygdala: 15 nTPM
  • basal ganglia: 15 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
2.32
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNTB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNTB2 as an antibody target. Whether an autoantibody or antibody against SNTB2 could matter depends on whether native SNTB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNTB2 is annotated at the cell surface, where native SNTB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNTB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNTB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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