Seroatlas · Human Serome Atlas

OLFM1

Noelin

Also known as: AMY, NOE1, NOE1_HUMAN, NOELIN, OlfA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99784
Gene: OLFM1
Ensembl: ENSG00000130558
Chromosome: 9
Canonical length: 485 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli,Cytosol
Secretome location: Secreted in brain
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q99784|OLFM1
     1  MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTKLSAA GGGTLDRSTG VLPTNPEESW
    61  QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ
   121  YVEKMENQMK GLESKFKQVE ESHKQHLARQ FKAIKAKMDE LRPLIPVLEE YKADAKLVLQ
   181  FKEEVQNLTS VLNELQEEIG AYDYDELQSR VSNLEERLRA CMQKLACGKL TGISDPVTVK
   241  TSGSRFGSWM TDPLAPEGDN RVWYMDGYHN NRFVREYKSM VDFMNTDNFT SHRLPHPWSG
   301  TGQVVYNGSI YFNKFQSHII IRFDLKTETI LKTRSLDYAG YNNMYHYAWG GHSDIDLMVD
   361  ESGLWAVYAT NQNAGNIVVS RLDPVSLQTL QTWNTSYPKR SAGEAFIICG TLYVTNGYSG
   421  GTKVHYAYQT NASTYEYIDI PFQNKYSHIS MLDYNPKDRA LYAWNNGHQI LYNVTLFHVI
   481  RSDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 907 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 907 nTPM
amygdala: 616 nTPM
hippocampal formation: 613 nTPM
cerebellum: 217 nTPM
hypothalamus: 137 nTPM
midbrain: 125 nTPM

Single-cell type

brain excitatory neurons: 160 nCPM
vascular endothelial cells: 101 nCPM
schwann cells: 78 nCPM
bergmann glia: 69 nCPM
other brain neurons: 69 nCPM
lactotrophs: 64 nCPM

Immune cell

intermediate monocyte: 2.8 nTPM
myeloid DC: 2.6 nTPM
classical monocyte: 1.8 nTPM
non-classical monocyte: 0.7 nTPM
total PBMC: 0.4 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 667 nTPM
hippocampal formation: 469 nTPM
amygdala: 361 nTPM
basal ganglia: 351 nTPM
white matter: 284 nTPM
thalamus: 171 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 3.41
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OLFM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFM1 as an antibody target. Whether an autoantibody or antibody against OLFM1 could matter depends on whether native OLFM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFM1 is annotated as secreted, so native OLFM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...