Seroatlas · Human Serome Atlas

HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Also known as: BRAF25, BRAF35, HM20B_HUMAN, HMGX2, HMGXB2, SMARCE1r, SOXL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0W2
Gene
HMG20B
Ensembl
ENSG00000064961
Chromosome
19
Canonical length
317 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9P0W2|HMG20B
     1  MSHGPKQPGA AAAPAGGKAP GQHGGFVVTV KQERGEGPRA GEKGSHEEEP VKKRGWPKGK
    61  KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI TKMLGAEWSK LQPTEKQRYL
   121  DEAEREKQQY MKELRAYQQS EAYKMCTEKI QEKKIKKEDS SSGLMNTLLN GHKGGDCDGF
   181  STFDVPIFTE EFLDQNKARE AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL
   241  EERRTLALQQ QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHEK
   301  LIVRIKEILA QVASEHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMG20B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 71 nTPM
  • prostate: 67 nTPM
  • skin: 56 nTPM
  • colon: 56 nTPM
  • kidney: 55 nTPM
  • liver: 53 nTPM

Single-cell type

  • syncytiotrophoblasts: 410 nCPM
  • extravillous trophoblasts: 367 nCPM
  • platelets: 359 nCPM
  • melanocytes: 253 nCPM
  • migrating cytotrophoblasts: 190 nCPM
  • goblet cells: 157 nCPM

Immune cell

  • non-classical monocyte: 77 nTPM
  • intermediate monocyte: 70 nTPM
  • classical monocyte: 68 nTPM
  • eosinophil: 66 nTPM
  • myeloid DC: 66 nTPM
  • NK-cell: 60 nTPM

Brain region

  • white matter: 34 nTPM
  • medulla oblongata: 33 nTPM
  • thalamus: 28 nTPM
  • spinal cord: 26 nTPM
  • pons: 26 nTPM
  • choroid plexus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.69
gnomAD missense Z
2.23
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMG20B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMG20B as an antibody target. Whether an autoantibody or antibody against HMG20B could matter depends on whether native HMG20B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMG20B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMG20B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HMG20B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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