Seroatlas · Human Serome Atlas

SNTG1

Gamma-1-syntrophin

Also known as: G1SYN, SNTG1_HUMAN, SYN4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSN8
Gene: SNTG1
Ensembl: ENSG00000147481
Chromosome: 8
Canonical length: 517 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q9NSN8|SNTG1
     1  MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP FYSGERTVTI
    61  RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF IGDAILQING INVRKCRHEE
   121  VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL NEDCACAPSD QSSGTSSPLC DSGLHLNYHP
   181  NNTDTLSCSS WPTSPGLRWE KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC
   241  TGIIQCLSAE DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD
   301  RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL LDRRKQCFTV
   361  QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT YACVLESHLM GLTIDFSTGF
   421  ICFDAATKAV LWRYKFSQLK GSSDDGKSKI KFLFQNPDTK QIEAKELEFS NLFAVLHCIH
   481  SFFAAKVACL DPLFLGNQAT ASTAASSATT SKAKYTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNTG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.7 nTPM
basal ganglia: 3.9 nTPM
hippocampal formation: 3.1 nTPM
hypothalamus: 2.6 nTPM
spleen: 2.6 nTPM
amygdala: 2.2 nTPM

Single-cell type

oligodendrocyte progenitor cells: 2,991 nCPM
brain inhibitory neurons: 1,848 nCPM
retinal amacrine cells: 1,411 nCPM
other brain neurons: 1,306 nCPM
brain excitatory neurons: 1,279 nCPM
thyrotrophs: 982 nCPM

Immune cell

basophil: 0.5 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 45 nTPM
hippocampal formation: 35 nTPM
basal ganglia: 35 nTPM
hypothalamus: 34 nTPM
white matter: 31 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.16
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell communication

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNTG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNTG1 as an antibody target. Whether an autoantibody or antibody against SNTG1 could matter depends on whether native SNTG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNTG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNTG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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