Seroatlas · Human Serome Atlas

SNTB1

Beta-1-syntrophin

Also known as: 59-DAP, A1B, BSYN2, SNT2, SNT2B1, SNTB1_HUMAN, TIP-43

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13884
Gene: SNTB1
Ensembl: ENSG00000172164
Chromosome: 8
Canonical length: 538 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q13884|SNTB1
     1  MAVAAAAAAA GPAGAGGGRA QRSGLLEVLV RDRWHKVLVN LSEDALVLSS EEGAAAYNGI
    61  GTATNGSFCR GAGAGHPGAG GAQPPDSPAG VRTAFTDLPE QVPESISNQK RGVKVLKQEL
   121  GGLGISIKGG KENKMPILIS KIFKGLAADQ TQALYVGDAI LSVNGADLRD ATHDEAVQAL
   181  KRAGKEVLLE VKYMREATPY VKKGSPVSEI GWETPPPESP RLGGSTSDPP SSQSFSFHRD
   241  RKSIPLKMCY VTRSMALADP ENRQLEIHSP DAKHTVILRS KDSATAQAWF SAIHSNVNDL
   301  LTRVIAEVRE QLGKTGIAGS REIRHLGWLA EKVPGESKKQ WKPALVVLTE KDLLIYDSMP
   361  RRKEAWFSPV HTYPLLATRL VHSGPGKGSP QAGVDLSFAT RTGTRQGIET HLFRAETSRD
   421  LSHWTRSIVQ GCHNSAELIA EISTACTYKN QECRLTIHYE NGFSITTEPQ EGAFPKTIIQ
   481  SPYEKLKMSS DDGIRMLYLD FGGKDGEIQL DLHSCPKPIV FIIHSFLSAK ITRLGLVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNTB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

liver: 84 nTPM
adrenal gland: 60 nTPM
thyroid gland: 57 nTPM
pancreas: 42 nTPM
choroid plexus: 37 nTPM
salivary gland: 33 nTPM

Single-cell type

choroid plexus epithelial cells: 1,500 nCPM
adrenal cortex cells: 1,124 nCPM
renal collecting duct intercalated cells: 1,009 nCPM
salivary ionocytes: 918 nCPM
mucous neck cells: 470 nCPM
alveolar cells type 2: 406 nCPM

Immune cell

eosinophil: 2.7 nTPM
gdT-cell: 2.2 nTPM
basophil: 1.9 nTPM
NK-cell: 1.6 nTPM
memory CD8 T-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

choroid plexus: 87 nTPM
hypothalamus: 23 nTPM
midbrain: 22 nTPM
thalamus: 16 nTPM
medulla oblongata: 14 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: -0.92
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

muscle contraction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNTB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNTB1 as an antibody target. Whether an autoantibody or antibody against SNTB1 could matter depends on whether native SNTB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNTB1 is annotated at the cell surface, where native SNTB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNTB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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