Seroatlas · Human Serome Atlas

NECTIN2

Nectin-2

Also known as: CD112, HVEB, NECT2_HUMAN, Nectin-2, PRR2, PVRL2, PVRR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92692
Gene
NECTIN2
Ensembl
ENSG00000130202
Chromosome
19
Canonical length
538 aa
Protein class
CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Mitotic spindle

OverviewNCBI Gene

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q92692|NECTIN2
     1  MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV ELPCHLLPPV
    61  PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL
   121  QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV
   181  ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV
   241  EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS
   301  GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTAGAGATGG
   361  IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL EGPPSYKPPT PKAKLEAQEM
   421  PSQLFTLGAS EHSPLKTPYF DAGASCTEQE MPRYHELPTL EERSGPLHPG ATSLGSPIPV
   481  PPGPPAVEDV SLDLEDEEGE EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NECTIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • liver: 114 nTPM
  • choroid plexus: 93 nTPM
  • adrenal gland: 78 nTPM
  • kidney: 76 nTPM
  • esophagus: 75 nTPM
  • placenta: 72 nTPM

Single-cell type

  • esophageal apical cells: 598 nCPM
  • decidual stromal cells: 325 nCPM
  • urothelial cells: 296 nCPM
  • granulosa cells: 294 nCPM
  • endometrial luminal cells: 268 nCPM
  • breast hormone-responsive cells: 266 nCPM

Immune cell

  • eosinophil: 10 nTPM
  • myeloid DC: 2.7 nTPM
  • classical monocyte: 2 nTPM
  • neutrophil: 1.9 nTPM
  • basophil: 1.8 nTPM
  • intermediate monocyte: 0.7 nTPM

Brain region

  • choroid plexus: 52 nTPM
  • medulla oblongata: 35 nTPM
  • thalamus: 33 nTPM
  • hypothalamus: 29 nTPM
  • midbrain: 29 nTPM
  • pons: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NECTIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NECTIN2 as an antibody target. Whether an autoantibody or antibody against NECTIN2 could matter depends on whether native NECTIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NECTIN2 is annotated at the cell surface, where native NECTIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NECTIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NECTIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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