Seroatlas · Human Serome Atlas

SDF2L1

Stromal cell-derived factor 2-like protein 1

Also known as: AP000553.C22.4, OTTHUMT00000075032, SDF2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCN8
Gene: SDF2L1
Ensembl: ENSG00000128228
Chromosome: 22
Canonical length: 221 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables misfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q9HCN8|SDF2L1
     1  MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR VRLHSHDIKY
    61  GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC GQAVRLTHVL TGKNLHTHHF
   121  PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREAAV RFQHVGTSVF LSVTGEQYGS
   181  PIRGQHEVHG MPSANTHNTW KAMEGIFIKP SVEPSAGHDE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDF2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 168 nTPM

Expression across tissuesHPA

Tissue

liver: 168 nTPM
pancreas: 97 nTPM
thyroid gland: 92 nTPM
pituitary gland: 78 nTPM
spleen: 70 nTPM
salivary gland: 50 nTPM

Single-cell type

epididymal principal cells: 1,250 nCPM
plasma cells: 762 nCPM
extravillous trophoblasts: 455 nCPM
early primary spermatocytes: 359 nCPM
hepatocytes: 325 nCPM
epididymal efferent duct ciliated cells: 298 nCPM

Immune cell

plasmacytoid DC: 219 nTPM
gdT-cell: 174 nTPM
memory CD8 T-cell: 157 nTPM
memory B-cell: 132 nTPM
MAIT T-cell: 131 nTPM
T-reg: 127 nTPM

Brain region

choroid plexus: 30 nTPM
hypothalamus: 27 nTPM
medulla oblongata: 23 nTPM
white matter: 19 nTPM
thalamus: 19 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.19
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDF2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDF2L1 as an antibody target. Whether an autoantibody or antibody against SDF2L1 could matter depends on whether native SDF2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDF2L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDF2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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