Seroatlas · Human Serome Atlas

TANC1

Protein TANC1

Also known as: KIAA1728, ROLSB, TANC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0D5
Gene: TANC1
Ensembl: ENSG00000115183
Chromosome: 2
Canonical length: 1861 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1861 residues, UniProt reviewed canonical sequence.

>Q9C0D5|TANC1
     1  MLKAVLKKSR EGGKGGKKEA GSDFGPETSP VLHLDHSADS PVSSLPTAED TYRVSLAKGV
    61  SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV PGDAVIMPFR EVAKPTEPDE
   121  HEAKADNEPS CSPAAQELLT RLGFLLGEGI PSATHITIED KNETMCTALS QGISPCSTLT
   181  SSTASPSTDS PCSTLNSCVS KTAANKSPCE TISSPSSTLE SKDSGIIATI TSSSENDDRS
   241  GSSLEWNKDG NLRLGVQKGV LHDRRADNCS PVAEEETTGS AESTLPKAES SAGDGPVPYS
   301  QGSSSLIMPR PNSVAATSST KLEDLSYLDG QRNAPLRTSI RLPWHNTAGG RAQEVKARFA
   361  PYKPQDILLK PLLFEVPSIT TDSVFVGRDW LFHQIEENLR NTELAENRGA VVVGNVGFGK
   421  TAIISKLVAL SCHGSRMRQI ASNSPGSSPK TSDPTQDLHF TPLLSPSSST SASSTAKTPL
   481  GSISAENQRP REDAVKYLAS KVVAYHYCQA DNTYTCLVPE FVHSIAALLC RSHQLAAYRD
   541  LLIKEPQLQS MLSLRSCVQD PVAAFKRGVL EPLTNLRNEQ KIPEEEYIIL IDGLNEAEFH
   601  KPDYGDTLSS FITKIISKFP AWLKLIVTVR ANFQEIISAL PFVKLSLDDF PDNKDIHSDL
   661  HAYVQHRVHS SQDILSNISL NGKADATLIG KVSSHLVLRS LGSYLYLKLT LDLFQRGHLV
   721  IKSASYKVVP VSLSELYLLQ CNMKFMTQSA FERALPILNV ALASLHPMTD EQIFQAINAG
   781  HIQGEQGWED FQQRMDALSC FLIKRRDKTR MFCHPSFREW LVWRADGENT AFLCEPRNGH
   841  ALLAFMFSRQ EGKLNRQQTM ELGHHILKAH IFKGLSKKTG ISSSHLQALW IGYSTEGLSA
   901  ALASLRNLYT PNVKVSRLLI LGGANVNYRT EVLNNAPILC VQSHLGHEEV VTLLLEFGAC
   961  LDGTSENGMT ALCYAAAAGH MKLVCLLTKK GVRVDHLDKK GQCALVHSAL RGHGDILQYL
  1021  LTCEWSPGPP QPGTLRKSHA LQQALTAAAS MGHSSVVQCL LGMEKEHEVE VNGTDTLWGE
  1081  TALTAAAGRG KLEVCELLLG HGAAVSRTNR RGVPPLFCAA RQGHWQIVRL LLERGCDVNL
  1141  SDKQGRTPLM VAACEGHLST VEFLLSKGAA LSSLDKEGLS ALSWACLKGH RAVVQYLVEE
  1201  GAAIDQTDKN GRTPLDLAAF YGDAETVLYL VEKGAVIEHV DHSGMRPLDR AIGCRNTSVV
  1261  VALLRKGAKL GNAAWAMATS KPDILIILLQ KLMEEGNVMY KKGKMKEAAQ RYQYALRKFP
  1321  REGFGEDMRP FNELRVSLYL NLSRCRRKTN DFGMAEEFAS KALELKPKSY EAFYARARAK
  1381  RNSRQFVAAL ADLQEAVKLC PTNQEVKRLL ARVEEECKQL QRSQQQKQQG PLPAPLNDSE
  1441  NEEDTPTPGL SDHFHSEETE EEETSPQEES VSPTPRSQPS SSVPSSYIRN LQEGLQSKGR
  1501  PVSPQSRAGI GKSLREPVAQ PGLLLQPSKQ AQIVKTSQHL GSGQSAVRNG SMKVQISSQN
  1561  PPPSPMPGRI AATPAGSRTQ HLEGTGTFTT RAGCGHFGDR LGPSQNVRLQ CGENGPAHPL
  1621  PSKTKTTERL LSHSSVAVDA APPNQGGLAT CSDVRHPASL TSSGSSGSPS SSIKMSSSTS
  1681  SLTSSSSFSD GFKVQGPDTR IKDKVVTHVQ SGTAEHRPRN TPFMGIMDKT ARFQQQSNPP
  1741  SRSWHCPAPE GLLTNTSSAA GLQSANTEKP SLMQVGGYNN QAKTCSVSTL SASVHNGAQV
  1801  KELEESKCQI PVHSQENRIT KTVSHLYQES ISKQQPHISN EAHRSHLTAA KPKRSFIESN
  1861  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TANC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 21 nTPM
skin: 19 nTPM
placenta: 13 nTPM
smooth muscle: 12 nTPM
esophagus: 12 nTPM
lung: 12 nTPM

Single-cell type

retinal ganglion cells: 858 nCPM
retinal horizontal cells: 855 nCPM
podocytes: 808 nCPM
cardiomyocytes: 557 nCPM
alveolar cells type 1: 460 nCPM
basal keratinocytes: 409 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 54 nTPM
white matter: 49 nTPM
medulla oblongata: 49 nTPM
pons: 44 nTPM
cerebellum: 43 nTPM
hypothalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TANC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TANC1 as an antibody target. Whether an autoantibody or antibody against TANC1 could matter depends on whether native TANC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TANC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TANC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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