Seroatlas · Human Serome Atlas

BEGAIN

Brain-enriched guanylate kinase-associated protein

Also known as: BEGIN_HUMAN, KIAA1446

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUH8
Gene
BEGAIN
Ensembl
ENSG00000183092
Chromosome
14
Canonical length
593 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable kinase activity. Predicted to be involved in evoked excitatory postsynaptic potential and regulation of postsynaptic neurotransmitter receptor activity. Predicted to be located in dendrite; nucleus; and presynapse. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q9BUH8|BEGAIN
     1  MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL EKVTEKLRRI
    61  QSNYMALQRI NQELEDKLYR MGQHYEEEKR ALSHEIVALN SHLLEAKVTI DKLSEDNELY
   121  RKDCNLAAQL LQCSQTYGRV HKVSELPSDF QERVSLHMEK HGCSLPSPLC HPAYADSVPT
   181  CVIAKVLEKP DPASLSSRLS DASARDLAFC DGVEKPGPRP PYKGDIYCSD TALYCPEERR
   241  RDRRPSVDAP VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPA GFQHEAFPSY AGSLPTSSSY
   301  SSFSATSEEK EHAQASTLTA SQQAIYLNSR DELFDRKPPA TTYEGSPRFA KATAAVAAPL
   361  EAEVAPGFGR TMSPYPAETF RFPASPGPQQ ALMPPNLWSL RAKPGTARLP GEDMRGQWRP
   421  LSVEDIGAYS YPVSAAGRAS PCSFSERYYG GAGGSPGKKA DGRASPLYAS YKADSFSEGD
   481  DLSQGHLAEP CFLRAGGDLS LSPGRSADPL PGYAPSEGGD GDRLGVQLCG TASSPEPEQG
   541  SRDSLEPSSM EASPEMHPAA RLSPQQAFPR TGGSGLSRKD SLTKAQLYGT LLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEGAIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 54 nTPM
  • cerebral cortex: 43 nTPM
  • amygdala: 37 nTPM
  • hippocampal formation: 37 nTPM
  • basal ganglia: 24 nTPM
  • pancreas: 23 nTPM

Single-cell type

  • retinal horizontal cells: 319 nCPM
  • early spermatids: 37 nCPM
  • thyrotrophs: 36 nCPM
  • gonadotrophs: 35 nCPM
  • brain excitatory neurons: 31 nCPM
  • mast cells: 31 nCPM

Immune cell

  • eosinophil: 2.8 nTPM
  • basophil: 0.8 nTPM
  • intermediate monocyte: 0.6 nTPM
  • non-classical monocyte: 0.5 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • neutrophil: 0.2 nTPM

Brain region

  • hippocampal formation: 47 nTPM
  • cerebral cortex: 44 nTPM
  • amygdala: 36 nTPM
  • cerebellum: 36 nTPM
  • basal ganglia: 36 nTPM
  • white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.24
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • evoked excitatory postsynaptic potential

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEGAIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEGAIN as an antibody target. Whether an autoantibody or antibody against BEGAIN could matter depends on whether native BEGAIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEGAIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEGAIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BEGAIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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