DEAD box RNA helicase
IPR050079
Definition
The DEAD box helicase family is involved in various RNA metabolic processes including ribosome biogenesis, RNA degradation, mRNA splicing, and RNAi-mediated gene silencing. Members of this family are characterized by the presence of conserved motifs, including the Q motif, which controls ATP binding and hydrolysis. These proteins exhibit RNA-dependent ATPase activity and RNA unwinding activity, facilitating the remodeling of RNA structures and RNA-protein interactions. They are essential for the normal formation of ribosomal subunits and pre-rRNA processing, contributing to the assembly and stability of ribonucleoprotein complexes. Some subfamilies within this group are also implicated in cellular processes such as apoptosis, cell cycle progression, and response to stress, highlighting their diverse roles in RNA metabolism.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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