Clathrin adaptor complex, small chain

Definition

Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer PMID:15261670. This entry represents the small sigma subunit of various adaptins from different AP clathrin adaptor complexes (including AP1, AP2, AP3 and AP4), and the zeta subunit of various coatomer (COP) adaptors. The small sigma subunit of AP proteins have been characterised in several species [[cite:PMID:8157009], [cite:PMID:8373805], [cite:PMID:8157009], [cite:PMID:9002613]]. The sigma subunit plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The zeta subunit of coatomers (zeta-COP) is required for coatomer binding to Golgi membranes and for coat-vesicle assembly [[cite:PMID:8276893], [cite:PMID:14729954]].

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• AP1S1
• AP1S2
• AP1S3
• AP2S1
• AP3S1
• AP3S2
• COPZ1